发明授权
- 专利标题: Subtilisin mutants
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申请号: US958885申请日: 1992-10-09
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公开(公告)号: US5204015A公开(公告)日: 1993-04-20
- 发明人: Robert M. Caldwell , David A. Estell , Thomas P. Graycar
- 申请人: Robert M. Caldwell , David A. Estell , Thomas P. Graycar
- 申请人地址: CA So. San Francisco
- 专利权人: Genencor International, Inc.
- 当前专利权人: Genencor International, Inc.
- 当前专利权人地址: CA So. San Francisco
- 主分类号: C11D3/386
- IPC分类号: C11D3/386 ; C12N9/54 ; C12N9/56 ; C12N15/10 ; C12N15/75
摘要:
Novel carbonyl hydrolase mutants derived from the DNA sequences of naturally-occurring or recombinant non-human carbonyl hydrolases are disclosed. The mutant carbonyl hydrolases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant carbonyl hydrolase to generate the substitution of one or more amino acid residues in the amino acid sequence of a precursor carbonyl hydrolase. Such mutant carbonyl hydrolases have properties which are different from those of the precursor hydrolase and are especially useful in detergent formulations. The substituted amino acid residues correspond to position +123 and/or +274 in Bacillus amyloliquefaciens subtilisin.
公开/授权文献
- US5846728A Oligonucleotide-polyamide conjugates 公开/授权日:1998-12-08