发明授权
US5204355A 15-nitro-2.beta., 3.beta.-dihydro- and
15-nitro-2.beta.,3.beta.,6,7-tetrahydrotabersonine derivatives,
pharmaceutical compositions containing them and process for preparing
same
失效
15-NITRO-2 + 62,3（BETA）-DIHYDRO-和15-NITRO-2（BETA），3（BETA），6,7-四氢异喹啉衍生物，含有它们的药物组合物及其制备方法
- 专利标题： 15-nitro-2.beta., 3.beta.-dihydro- and 15-nitro-2.beta.,3.beta.,6,7-tetrahydrotabersonine derivatives, pharmaceutical compositions containing them and process for preparing same
- 专利标题（中）： 15-NITRO-2 + 62,3（BETA）-DIHYDRO-和15-NITRO-2（BETA），3（BETA），6,7-四氢异喹啉衍生物，含有它们的药物组合物及其制备方法
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申请号： US806975申请日： 1991-12-12
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公开(公告)号： US5204355A公开(公告)日： 1993-04-20
- 发明人: Bela Zsadon , Margit Barta n/e/ e Bukovecz , Maria Szilasi , Tibor Keve , Janos Galambos , Viktoria Bolya nee Kassay , Sandor Szabo , Emilia Repasi, nee Balogh , Laszlo Szporny , Bela Kiss , Egon Karpati , Eva Palosi , Zsolt Szombathelyi , Adam Sarkadi , Erzsebet Lapis , Aniko Gere , Mih,acu/a/ ly Bodo , Katalin Csomor , Judit Laszy , Zsolt Szentirmay
- 申请人： Bela Zsadon , Margit Barta n/e/ e Bukovecz , Maria Szilasi , Tibor Keve , Janos Galambos , Viktoria Bolya nee Kassay , Sandor Szabo , Emilia Repasi, nee Balogh , Laszlo Szporny , Bela Kiss , Egon Karpati , Eva Palosi , Zsolt Szombathelyi , Adam Sarkadi , Erzsebet Lapis , Aniko Gere , Mih,acu/a/ ly Bodo , Katalin Csomor , Judit Laszy , Zsolt Szentirmay
- 申请人地址： HUX Budapest
- 专利权人： Richter Gedeon Vegyeszeti Gyar RT.
- 当前专利权人： Richter Gedeon Vegyeszeti Gyar RT.
- 当前专利权人地址： HUX Budapest
- 优先权： HUX8313/90 19901218
- 主分类号： A61K31/435
- IPC分类号： A61K31/435 ; A61P25/28 ; A61P43/00 ; C07D471/16 ; C07D471/20
摘要：
The invention relates to novel 15-nitro-2.beta.,3.beta.-dihydro- and 15-nitro-2.beta.,3.beta.,6,7-tetrahydrotabersonine derivatives of the formula (I), ##STR1## wherein R.sup.1 stands for hydrogen;R.sup.2 stands for hydrogen or a C.sub.1-6 alkyl group; and the symbol represents a single or double bond as well as their salts.The invention further relates to pharmaceutical compositions containing the above compounds as well as a process for the preparation of the above compounds of formula (I) and of the pharmaceutical compositions.The compounds of formula (I) exert a reducing or inhibitory effect on cerebral edema and show antihypoxic properties. Thus, they are useful for the prevention or treatment of brain injuries of various origin induced by hypoxia of the brain.
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