发明授权
- 专利标题： Farnesylated tetrahydro-naphthalenols as hypolipidemic agents
- 专利标题（中）： 法呢基化四氢萘酚作为降血脂药
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申请号： US749778申请日： 1991-08-26
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公开(公告)号： US5204373A公开(公告)日： 1993-04-20
- 发明人: Bradley C. Pearce
- 申请人： Bradley C. Pearce
- 申请人地址： NY New York
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： NY New York
- 主分类号： C07C39/23
- IPC分类号： C07C39/23 ; C07C43/215 ; C07C43/23 ; C07C45/67 ; C07C45/68 ; C07C49/747 ; C07C49/753 ; C07C309/65 ; C07C317/18
摘要：
The invention relates to novel farnesylated tetrahydro-naphthalenols, that inhibit HMGR activity which results in a decrease in serum total cholesterol, a decrease in LDL cholesterol levels, and inhibition of LDL oxidation. The farnesylated tetrahydro-naphthalenols of the present invention are thus useful for cholesterol/lipid lowering in cases of hypercholesterolemia, hyperlipidemia, and atherosclerosis.
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