发明授权
US5214061A Method of using p-acylaminophenoxycarbamates and derivatives as
analgesics
失效
使用对氨基苯氧基氨基甲酸酯和衍生物作为止痛剂的方法
- 专利标题: Method of using p-acylaminophenoxycarbamates and derivatives as analgesics
- 专利标题(中): 使用对氨基苯氧基氨基甲酸酯和衍生物作为止痛剂的方法
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申请号: US837190申请日: 1992-02-18
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公开(公告)号: US5214061A公开(公告)日: 1993-05-25
- 发明人: Richard C. Allen , Raymond W. Kosley, Jr. , Bettina Spahl
- 申请人: Richard C. Allen , Raymond W. Kosley, Jr. , Bettina Spahl
- 申请人地址: NJ Somerville
- 专利权人: Hoechst-Roussel Pharmaceuticals Inc.
- 当前专利权人: Hoechst-Roussel Pharmaceuticals Inc.
- 当前专利权人地址: NJ Somerville
- 主分类号: C07C271/40
- IPC分类号: C07C271/40 ; C07C271/44 ; C07D213/54 ; C07D521/00
摘要:
This invention relates to p-acylaminophenoxycarbamates having the formula ##STR1## where R.sub.1 and R.sub.2 are each independently hydrogen, loweralkyl, aryl and arylloweralkyl; R.sub.3 is hydrogen, loweralkyl, arylloweralkyl; R.sub.4 is hydrogen, loweralkyl, formyl, alkylcarbonyl, arylloweralkyl, phenylcarbonyl, arylloweralkylcarbonyl, substituted phenylcarbonyl, pyridylcarbonyl, and substituted pyridylcarbonyl with the proviso that if R.sub.4 contains a carbonyl group directly attached to the oxygen of the N-O moiety, R.sub.3 cannot be hydrogen; or R.sub.3 and R.sub.4 taken together from a heterocyclic ring selected from the group consisting of imidazole or loweralkylimidazole; X is hydrogen, halogen, hydroxy, loweralkyl, loweralkoxy, nitro, amino or trifluoromethyl; and p is an integer selected from 0 and 1; the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and stereoisomers and racemic mixtures thereof. The compounds of this invention display utility as analgesics.
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