发明授权
US5225427A 10-substituted ether derivatives of dihydroartemisinin, process for
their preparation and their use as antiprotozoal agents
失效
二氢青蒿素的10-取代醚衍生物，其制备方法及其作为抗原虫剂的用途
- 专利标题： 10-substituted ether derivatives of dihydroartemisinin, process for their preparation and their use as antiprotozoal agents
- 专利标题（中）： 二氢青蒿素的10-取代醚衍生物，其制备方法及其作为抗原虫剂的用途
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申请号： US799179申请日： 1991-11-27
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公开(公告)号： US5225427A公开(公告)日： 1993-07-06
- 发明人: Bindumadhavan Venugopalan , Chintamani P. Bapat , Pravin J. Karnik , Bansi Lal , Dipak K. Chatterjee , Subramani N. Iver , Richard H. Rupp
- 申请人： Bindumadhavan Venugopalan , Chintamani P. Bapat , Pravin J. Karnik , Bansi Lal , Dipak K. Chatterjee , Subramani N. Iver , Richard H. Rupp
- 申请人地址： DEX Frankfurt am Main
- 专利权人： Hoechst Aktiengesellschaft
- 当前专利权人： Hoechst Aktiengesellschaft
- 当前专利权人地址： DEX Frankfurt am Main
- 优先权： EPX88116378.6 19881004
- 主分类号： C07D493/18
- IPC分类号： C07D493/18
摘要：
10-substituted ether derivatives of 3.alpha., 12.alpha.-Epoxy-3,4,5 5a.alpha., 6,7,8,8a.alpha.,9,10,12.beta., 12a-dodecahydro-10-hydroxy-3.beta.,6.alpha.,9.beta.-trimethylpyano-(4,3-j) (1,2) benzodioxepin, also known as Dihydroartemisinin or Dihydroquinghaosu (DHQ), pharmaceutically acceptable salts thereof, processes for their preparation and their use as chemotherapeutics against protozoal infections are provided.
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