发明授权
US5229403A Diaminotrifluoromethylpyridine derivatives and phospholipase A.sub.2
inhibitor containing them
失效
含有它们的二氨基三氟甲基吡啶衍生物和磷脂酶A2抑制剂
- 专利标题: Diaminotrifluoromethylpyridine derivatives and phospholipase A.sub.2 inhibitor containing them
- 专利标题(中): 含有它们的二氨基三氟甲基吡啶衍生物和磷脂酶A2抑制剂
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申请号: US723377申请日: 1991-06-28
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公开(公告)号: US5229403A公开(公告)日: 1993-07-20
- 发明人: Takahiro Haga , Hideo Sugi , Itaru Shigehara , Shinji Odawara , Syuichi Yotsuya , Hirohiko Kimura , Kazuhiro Yamamoto
- 申请人: Takahiro Haga , Hideo Sugi , Itaru Shigehara , Shinji Odawara , Syuichi Yotsuya , Hirohiko Kimura , Kazuhiro Yamamoto
- 申请人地址: JPX Osaka
- 专利权人: Ishihara Sangyo Kaisha Ltd.
- 当前专利权人: Ishihara Sangyo Kaisha Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: JPX2-181999 19900710
- 主分类号: A61K31/4427
- IPC分类号: A61K31/4427 ; A61P5/48 ; A61P29/00 ; C07D213/75 ; C07D213/76 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D413/12 ; C07D417/12 ; C07D453/02 ; C07D495/04
摘要:
A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1 (W.sup.2 W.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N R.sup.11)R.sup.12, wherein each of R.sup.1, R.sup.6 and R.sup.9, which are independent from one another, is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted or a polycyclic heterocycle group which may be substituted, each of R.sup.2 and R.sup.7, which are independent from each other, is alkyl which may be substituted, alkoxy which may be substituted, phenyl which may be substituted or phenoxy which may be substituted, each of R.sup.3, R.sup.8 and R.sup.10, which are independent from one another, is alkyl which may be substituted, alkenyl which may be substituted, alkynyl which may be substituted, cycloalkyl which may be substituted, phenyl which may be substituted or benzyl which may be substituted, each of R.sup.4, R.sup.5, R.sup.11 and R.sup.12, which are independent from one another, is alkyl which may be substituted, each of W.sup.1, W.sup.2, W.sup.3 and W.sup.4, which are independent from one another, is an oxygen atom or a sulfur atom, and m is 0 or 1, provided that a combination wherein one of X and Y is --COCF.sub.2 X.sup.1 wherein X.sup.1 is a hydrogen atom, a halogen atom, alkyl or haloalkyl, and the other is --COCF.sub.2 X.sup.2 wherein X.sub.2 is a hydrogen atom, a halogen atom, alkyl, haloalkyl or alkylcarbonyl, or --COOX.sup.3 wherein X.sup.3 is alkyl which may be substituted or phenyl which may be substituted, is excluded.
公开/授权文献
- US4709410A Frequency conversion circuits 公开/授权日:1987-11-24
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