发明授权
- 专利标题: Process for the preparation of phenylethanolaminotetralins
- 专利标题(中): 制备苯乙醇氨基三苯乙烯的方法
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申请号: US990762申请日: 1992-12-15
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公开(公告)号: US5235103A公开(公告)日: 1993-08-10
- 发明人: Robert Boigegrain , Roberto Cecchi , Sergio Boveri
- 申请人: Robert Boigegrain , Roberto Cecchi , Sergio Boveri
- 申请人地址: FRX Paris
- 专利权人: Sanofi
- 当前专利权人: Sanofi
- 当前专利权人地址: FRX Paris
- 优先权: FRX8711497 19870812; FRX8804219 19880330; FRX8807947 19880614
- 主分类号: C07C233/12
- IPC分类号: C07C233/12
摘要:
A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and R.sup.o is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy group, which comprises treating a mandelic acid with a 2-amino-7-hydroxytetralin, optionally alkylating with a lower alkyl haloacetate and reducing the amido group of the mandelamide into a methyleneamino group. The mandelamides intermediates are novel.
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