发明授权
- 专利标题： Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same
- 专利标题（中）： 哌啶衍生物和含有其的心律不齐的治疗和预防剂
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申请号： US930727申请日： 1992-08-14
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公开(公告)号： US5246946A公开(公告)日： 1993-09-21
- 发明人: Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
- 申请人： Hitoshi Oinuma , Motosuke Yamanaka , Kazutoshi Miyake , Tomonori Hoshiko , Norio Minami , Tadao Shoji , Yoshiharu Daiku , Kohei Sawada , Kenichi Nomoto
- 申请人地址： JPX Tokyo
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX62-209726 19870824; JPX62-209727 19870824; JPX62-209728 19870824
- 主分类号： C07D211/14
- IPC分类号： C07D211/14 ; C07D211/32 ; C07D211/54 ; C07D213/38 ; C07D401/06
摘要：
A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO2--, R2 is hydrogen or --(CH2)n--Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--,p is an integer of 1 to 4, R12 is hydrogen or a lower alkyl, Y' is --(CH2)m--A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents andR22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.