发明授权
- 专利标题: Percutaneous-administration-type pharmaceutical preparation of nitroglycerin
- 专利标题(中): 硝酸甘油经皮给药型药物制剂
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申请号: US680723申请日: 1991-04-04
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公开(公告)号: US5260064A公开(公告)日: 1993-11-09
- 发明人: Takashi Nakagawa , Hiroko Tsukahara , Masayasu Kurono , Makoto Sato , Tsutomu Ishida , Kazushi Tokita , Mitsuji Nakano
- 申请人: Takashi Nakagawa , Hiroko Tsukahara , Masayasu Kurono , Makoto Sato , Tsutomu Ishida , Kazushi Tokita , Mitsuji Nakano
- 申请人地址: JPX Osaka JPX Nagoya JPX Tokyo
- 专利权人: Sekisui Kagaku Kogyo Kabushiki Kaisha,Sanwa Kagaku Kenkyusho Co., Ltd.,Nippon Oil & Fats Co., Ltd.
- 当前专利权人: Sekisui Kagaku Kogyo Kabushiki Kaisha,Sanwa Kagaku Kenkyusho Co., Ltd.,Nippon Oil & Fats Co., Ltd.
- 当前专利权人地址: JPX Osaka JPX Nagoya JPX Tokyo
- 优先权: JPX2-92694 19900406
- 主分类号: A61K9/70
- IPC分类号: A61K9/70 ; A61K31/21 ; A61K47/14 ; A61L15/58 ; A61F13/02
摘要:
A percutaneous-administration-type pharmaceutical preparation of nitroglycerin is provided. The preparation comprises a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is placed on one surface of said backing, wherein said pressure-sensitive adhesive layer contains an alkyl (meth)acrylate (co)polymer in the concentration of 35-85% by weight, nitroglycerin in the concentration of 10-30% by weight, and a silicic acid anhydride in the concentration of 5-20% by weight, said (co)polymer contains as major (co)polymer components alkyl (meth)acrylates with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexyl methacrylate in the concentration of 40-100% by weight based on the total weight of said alkyl (meth)acrylates. The preparation makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for a long period of time. Also, even a compact preparation can supply a sufficient amount of nitroglycerin. Moreover, the preparation can be manufactured at low cost without any complicated process.
公开/授权文献
- US4713452A Process for preparation of azetidinone derivatives 公开/授权日:1987-12-15
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