公开(公告)号：US5260064A

公开(公告)日：1993-11-09

申请号：US680723

申请日：1991-04-04

申请人： Takashi Nakagawa ,  Hiroko Tsukahara ,  Masayasu Kurono ,  Makoto Sato ,  Tsutomu Ishida ,  Kazushi Tokita ,  Mitsuji Nakano

发明人： Takashi Nakagawa ,  Hiroko Tsukahara ,  Masayasu Kurono ,  Makoto Sato ,  Tsutomu Ishida ,  Kazushi Tokita ,  Mitsuji Nakano

IPC分类号： A61K9/70 ,  A61K31/21 ,  A61K47/14 ,  A61L15/58 ,  A61F13/02

CPC分类号： A61K9/7053 ,  A61K31/21 ,  A61K9/7061 ,  A61L15/58

摘要： A percutaneous-administration-type pharmaceutical preparation of nitroglycerin is provided. The preparation comprises a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is placed on one surface of said backing, wherein said pressure-sensitive adhesive layer contains an alkyl (meth)acrylate (co)polymer in the concentration of 35-85% by weight, nitroglycerin in the concentration of 10-30% by weight, and a silicic acid anhydride in the concentration of 5-20% by weight, said (co)polymer contains as major (co)polymer components alkyl (meth)acrylates with alkyl groups having 6 or more carbon atoms, which alkyl (meth)acrylates include 2-ethylhexyl methacrylate in the concentration of 40-100% by weight based on the total weight of said alkyl (meth)acrylates. The preparation makes it possible for nitroglycerin to be absorbed percutaneously at a controlled rate for a long period of time. Also, even a compact preparation can supply a sufficient amount of nitroglycerin. Moreover, the preparation can be manufactured at low cost without any complicated process.