发明授权
- 专利标题： Imidazopyridines as serotonergic 5-HT.sub.3 antagonists
- 专利标题（中）： 咪唑并吡啶作为5-羟色胺能5-HT3拮抗剂
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申请号： US666113申请日： 1991-03-07
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公开(公告)号： US5260303A公开(公告)日： 1993-11-09
- 发明人: Daniel P. Becker , Daniel L. Flynn , Alan E. Moormann , Roger Nosal , Clara I. Villamil
- 申请人： Daniel P. Becker , Daniel L. Flynn , Alan E. Moormann , Roger Nosal , Clara I. Villamil
- 申请人地址： IL Chicago
- 专利权人： G. D. Searle & Co.
- 当前专利权人： G. D. Searle & Co.
- 当前专利权人地址： IL Chicago
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/435 ; A61K31/445 ; A61K31/4468 ; A61K31/46 ; A61P43/00 ; C07C219/12 ; C07C233/62 ; C07D211/46 ; C07D211/58 ; C07D451/04 ; C07D451/06 ; C07D451/14 ; C07D453/02 ; C07D471/04 ; C07D471/06 ; C07D471/22 ; C07D487/04 ; C07D487/08 ; C07D519/00 ; C07D453/06
摘要：
The imidazopyridines compounds of the present invention are serotonergic 5-HT.sub.3 antagonists. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, gastric stasis, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
公开/授权文献
- US5908897A Silicone rubber composition 公开/授权日：1999-06-01
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