The sense circuit, for recognizing the virgin or programmed status of cells in storage devices, comprises a differential amplifier having a first input connected to a number of selectable matrix cells, through a first uncoupling circuit, a second input connected to a number of selectable reference virgin cells through a second uncoupling circuit, respective matrix and reference load transistors connected between each input of the amplifier and a supply voltage, and a current generator connected in parallel to the matrix cells and controlled by the first input of the amplifier to draw a current equal to a predetermined fraction of the current flowing through said first input.