发明授权
US5288501A Mechanically-stable, readily-disintegratable tablets made of small
preformed particles containing active ingredients
失效
机械稳定,容易崩解的片剂,由含有活性成分的小预成型颗粒制成
- 专利标题: Mechanically-stable, readily-disintegratable tablets made of small preformed particles containing active ingredients
- 专利标题(中): 机械稳定,容易崩解的片剂,由含有活性成分的小预成型颗粒制成
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申请号: US905036申请日: 1992-06-26
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公开(公告)号: US5288501A公开(公告)日: 1994-02-22
- 发明人: Eberhard Nurnberg , Erhard Seiller , Bernd Kuhn
- 申请人: Eberhard Nurnberg , Erhard Seiller , Bernd Kuhn
- 申请人地址: DEX Frankfurt
- 专利权人: Merz + Co. GmbH & Co.
- 当前专利权人: Merz + Co. GmbH & Co.
- 当前专利权人地址: DEX Frankfurt
- 优先权: DEX4122217 19910704
- 主分类号: A61J3/06
- IPC分类号: A61J3/06 ; A61K9/14 ; A61K9/20 ; A61K9/32 ; A61K9/36 ; A61K9/50
摘要:
The application discloses a process for the manufacture of mechanically-stable, readily-disintegratable tablets made of small preformed, preferably rounded, particles or pellets containing a high percentage of active ingredient in which--prior to compression--the particles are coated with an aqueous or aqueous/organic suspension containing water-soluble polyvinyl alcohol having an ester content of 19.4 to 6.7%, a disintegrant, and finely-divided cellulose, the remainder being excipients such as additional colloids, adjuvants, dyes, and/or flavors and the suspending liquid, and dried, the stable but readily-friable tablet product thus-produced, and a method of delivering an active ingredient by the employment of such a tablet for oral ingestion.
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