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US5288501A Mechanically-stable, readily-disintegratable tablets made of small preformed particles containing active ingredients 失效
机械稳定,容易崩解的片剂,由含有活性成分的小预成型颗粒制成

Mechanically-stable, readily-disintegratable tablets made of small
preformed particles containing active ingredients
摘要:
The application discloses a process for the manufacture of mechanically-stable, readily-disintegratable tablets made of small preformed, preferably rounded, particles or pellets containing a high percentage of active ingredient in which--prior to compression--the particles are coated with an aqueous or aqueous/organic suspension containing water-soluble polyvinyl alcohol having an ester content of 19.4 to 6.7%, a disintegrant, and finely-divided cellulose, the remainder being excipients such as additional colloids, adjuvants, dyes, and/or flavors and the suspending liquid, and dried, the stable but readily-friable tablet product thus-produced, and a method of delivering an active ingredient by the employment of such a tablet for oral ingestion.
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