发明授权
US5288751A [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl]
thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis
失效
[（取代的）烷基]呋喃基炔基和[取代的]烷基]噻吩基炔基-N-羟基脲抑制剂或白三烯生物合成
- 专利标题： [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis
- 专利标题（中）： [（取代的）烷基]呋喃基炔基和[取代的]烷基]噻吩基炔基-N-羟基脲抑制剂或白三烯生物合成
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申请号： US973100申请日： 1992-11-06
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公开(公告)号： US5288751A公开(公告)日： 1994-02-22
- 发明人: Dee W. Brooks , Andrew O. Stewart , Anwer Basha , Pramila Bhatia , James D. Ratajczyk
- 申请人： Dee W. Brooks , Andrew O. Stewart , Anwer Basha , Pramila Bhatia , James D. Ratajczyk
- 申请人地址： IL Abbott Park
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： IL Abbott Park
- 主分类号： A61K31/17
- IPC分类号： A61K31/17 ; A61K31/38 ; A61K31/381 ; A61K31/425 ; A61K31/426 ; A61K31/44 ; A61K31/4433 ; A61P9/00 ; A61P9/10 ; A61P11/00 ; A61P17/00 ; A61P25/00 ; A61P27/16 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07C273/18 ; C07C275/24 ; C07C275/64 ; C07D213/61 ; C07D277/28 ; C07D307/52 ; C07D333/20 ; C07D333/22 ; C07D405/06 ; C07D409/04 ; C07D409/06 ; C07D417/04 ; C07D307/36 ; A61K31/34
摘要：
The present invention relates to compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein Z is selected from optionally substituted phenyl, furyl, thienyl or thiazolyl; which inhibits leukotriene biosynthesis and is useful in the treatment of inflammatory disease states; also disclosed are leukotriene biosynthesis inhibiting compositions and a method for inhibiting 5-lipoxygenase activity and leukotriene biosynthesis.
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