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    Heterodimers of Glutamic Acid
    6.
    发明申请
    Heterodimers of Glutamic Acid 审中-公开

    公开(公告)号：US20190276393A1

    公开(公告)日：2019-09-12

    申请号：US16156289

    申请日：2018-10-10

    申请人： Molecular Insight Pharmaceuticals, Inc.

    发明人： John W. Babich ,  Craig N. Zimmerman ,  Kevin P. Maresca

    IPC分类号： C07C275/16 ,  A61K39/385 ,  C07D213/38 ,  C07B59/00 ,  C07C275/30 ,  C07C275/24 ,  C07C311/19

    摘要： Compounds of Formula (Ia) wherein R is a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl, a C1-C6 substituted or unsubstituted alkyl or —NR′R′, Q is C(O), O, NR′, S, S(O)2, C(O)2 (CH2)p Y is C(O), O, NR′, S, S(O)2, C(O)2 (CH2)p Z is H or C1-C4 alkyl, R′ is H, C(O), S(O)2, C(O)2, a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl or a C1-C6 substituted or unsubstituted alkyl, when substituted, aryl, heteroaryl and alkyl are substituted with halogen, C6-C12 heteroaryl, —NR′R′ or COOZ, which have diagnostic and therapetitic properties, such as the treatment and management of prostate cancer and other diseases related to NAALADase inhibition, Radiolabels can be incorporated into the structure through a variety of prosthetic groups attached at the X amino acid side chain via a carbon or hetero atom linkage.