A novel self-adhesive silicone rubber composition is disclosed which gives a cured silicone rubber capable of being firmly bonded to the surface of various kinds of substrate materials even without the pre-treatment of the substrate surface with a primer so that the composition is useful as a coating material in the preparation of a silicone rubber-coated cloth advantageous in respect of the firm adhesion of the cured silicone rubber layer to the substrate cloth. The composition is characterized by the formulation of a unique component which is an organosilane compound having an isocyanato-containing group and a hydrolyzable group in a molecule such as 3-isocyanatopropyl trimethoxy silane.