发明授权
US5318970A Isoxazole compounds, pharmaceutically acceptable salts thereof and
medical uses thereof
失效
异恶唑化合物，其药学上可接受的盐及其医疗用途
- 专利标题： Isoxazole compounds, pharmaceutically acceptable salts thereof and medical uses thereof
- 专利标题（中）： 异恶唑化合物，其药学上可接受的盐及其医疗用途
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申请号： US844561申请日： 1993-03-17
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公开(公告)号： US5318970A公开(公告)日： 1994-06-07
- 发明人: Masahiro Suzuki , Kenji Nozaki , Makoto Kajitani , Mitsugi Yasumoto , Naohiko Ono , Takashi Shindo
- 申请人： Masahiro Suzuki , Kenji Nozaki , Makoto Kajitani , Mitsugi Yasumoto , Naohiko Ono , Takashi Shindo
- 申请人地址： JPX Tokyo
- 专利权人： Taiho Pharmaceutical Co., Ltd.
- 当前专利权人： Taiho Pharmaceutical Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX2-253184 19900921
- 主分类号： A61K31/42
- IPC分类号： A61K31/42 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07D261/08 ; C07D413/12 ; A61K31/495 ; C07D413/06 ; C07D413/14
摘要：
A isoxazole compound represented by the formula (1): ##STR1## wherein R represents a hydrogen atom or a lower alkoxy group, R.sub.1 is a group represented by the formula (2): ##STR2## (wherein A represents --NH-- or --O--, B represents a methylene group or a carbonyl group, m is 0 or 1, n is an integer of 1 to 12, X represents a hydrogen atom, a hydroxy group or a lower alkoxycarbonyl group, Y represents a phenyl group which can be substituted with one or more halogen atoms, or a hydrogen atom), a group represented by the formula (3): ##STR3## (wherein Z represents a pyrimidinyl group), or a group represented by the formula (4): ##STR4## (wherein R.sub.2 represents a styryl group which can be substituted with one or more hydroxy groups); a pharmaceutically acceptable salt thereof; or a medical use thereof in a method of inhibiting lipoxygenase, inhibiting 5-lipoxygenase or inhibiting cyclooxygenase.
公开/授权文献
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