发明授权
US5328919A Pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl]
benzimidazole-7-carboxylate or a pharmaceutically acceptable salt
thereof and compositions and method of pharmaceutical use thereof
失效
2-乙氧基-1 - [[2' - （1H-四唑-5-基）联苯-4-基]苯并咪唑-7-羧酸酯或其药学上可接受的盐的新戊酰氧基甲基酯及其药物用途的组合物和方法
- 专利标题： Pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl] benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof and compositions and method of pharmaceutical use thereof
- 专利标题（中）： 2-乙氧基-1 - [[2' - （1H-四唑-5-基）联苯-4-基]苯并咪唑-7-羧酸酯或其药学上可接受的盐的新戊酰氧基甲基酯及其药物用途的组合物和方法
-
申请号： US997703申请日： 1993-01-05
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公开(公告)号： US5328919A公开(公告)日： 1994-07-12
- 发明人: Takehiko Naka , Kohei Nishikawa , Takeshi Kato
- 申请人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
- 申请人地址： JPX Osaka
- 专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX2-113148 19900427; JPX2-141942 19900530; JPX2-208662 19900806; JPX2-264579 19901001; JPX2-413679 19901224
- 主分类号： A61K31/415
- IPC分类号： A61K31/415 ; C07D235/02 ; C07D235/26 ; C07D235/28 ; C07D235/30 ; C07D403/10 ; C07D405/14 ; C07P257/04 ; A61K31/41
摘要：
Pivaloyloxymethyl2-ethoxy-1-[['-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II antagonistic activity and antihypertensive activity, thus being a useful therapeutic agent for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy or nephritis.
公开/授权文献
- US5915528A Protective stripe assemblies with concave-convex interfaces 公开/授权日：1999-06-29
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