发明授权
- 专利标题： Piperazine derivatives
- 专利标题（中）： 哌嗪衍生物
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申请号： US1428申请日： 1993-01-07
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公开(公告)号： US5340812A公开(公告)日： 1994-08-23
- 发明人: Ian A. Cliffe
- 申请人： Ian A. Cliffe
- 申请人地址： GBX Maidenhead
- 专利权人： John Wyeth & Brother, Limited
- 当前专利权人： John Wyeth & Brother, Limited
- 当前专利权人地址： GBX Maidenhead
- 优先权： GBX8909209.2 19890422; GBX8924323.2 19891028
- 主分类号： C07D205/04
- IPC分类号： C07D205/04 ; C07D221/20 ; C07D239/42 ; C07D295/084 ; C07D295/088 ; C07D295/125 ; C07D295/13 ; C07D295/145 ; C07D295/15 ; C07D295/185 ; C07D319/20 ; A61K31/495 ; C07D237/00 ; C07D295/00 ; C07D401/00
摘要：
Piperazine derivatives of formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula n is 1 or 2, R is hydrogen or lower alkyl, R.sup.1 is an aryl or nitrogen containing heteroaryl radical, R.sup.2 is hydrogen or lower alkyl, R.sup.3 is aryl, C.sub.4-8 alkyl or aryl(lower)alkyl, and X is a functionalised group of specified meaning. The compounds exhibit activity as 5-HT.sub.1A antagonists and can be used, inter alia, for the treatment of CNS disorders, such as anxiety.
公开/授权文献
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