发明授权
- 专利标题： Method of producing analgesia
- 专利标题（中）： 镇痛方法
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申请号： US81863申请日： 1993-06-23
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公开(公告)号： US5364842A公开(公告)日： 1994-11-15
- 发明人: Alan Justice , Tejinder Singh , Kishor C. Gohil , Karen L. Valentino
- 申请人： Alan Justice , Tejinder Singh , Kishor C. Gohil , Karen L. Valentino
- 申请人地址： CA Menlo Park
- 专利权人： Neurex Corporation
- 当前专利权人： Neurex Corporation
- 当前专利权人地址： CA Menlo Park
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/17 ; C07K14/435 ; G01N33/94 ; A61K37/00 ; A61K37/02 ; C07K5/00 ; C07K7/00
摘要：
A method of producing analgesia and enhancing opiate analgesia is disclosed. The method includes administering TVIA (SNX-185) or MVIIA (SNX-111) omega-conopeptide, or derivative thereof which is characterized by its ability to (a) inhibit voltage-gated calcium channels selectively in neuronal tissue, as evidenced by the peptide's ability to inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind to omega-conopeptide MVIIA binding sites present in neuronal tissue.
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