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公开(公告)号：US5364842A
公开(公告)日：1994-11-15
申请号：US81863
申请日：1993-06-23
IPC分类号： A61K38/00 , A61K38/17 , C07K14/435 , G01N33/94 , A61K37/00 , A61K37/02 , C07K5/00 , C07K7/00
CPC分类号： C07K14/43504 , A61K38/17 , C07K14/435 , G01N33/9486 , G01N2500/00
摘要： A method of producing analgesia and enhancing opiate analgesia is disclosed. The method includes administering TVIA (SNX-185) or MVIIA (SNX-111) omega-conopeptide, or derivative thereof which is characterized by its ability to (a) inhibit voltage-gated calcium channels selectively in neuronal tissue, as evidenced by the peptide's ability to inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind to omega-conopeptide MVIIA binding sites present in neuronal tissue.
摘要翻译： 公开了一种产生止痛和增强阿片镇痛的方法。 该方法包括施用TVIA（SNX-185）或MVIIA（SNX-111）ω-肽，或其衍生物，其特征在于其能够（a）在神经元组织中选择性抑制电压门控钙通道的能力，如肽的 抑制豚鼠回肠电刺激收缩的能力，和（b）结合存在于神经元组织中的ω-肽肽MVIIA结合位点。
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公开(公告)号：US5587454A
公开(公告)日：1996-12-24
申请号：US49794
申请日：1993-04-15
CPC分类号： C07K14/43504 , A61K38/17 , C07K14/435 , G01N33/9486 , G01N2500/00
摘要： Disclosed are novel omega conotoxin peptides effective in producing analgesia.
摘要翻译： 公开了有效地产生止痛的新型ω-芋螺毒素肽。
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公开(公告)号：US5824645A
公开(公告)日：1998-10-20
申请号：US742774
申请日：1996-11-01
申请人： Alan Justice , Tejinder Singh , Kishor Chandra Gohil , Karen L. Valentino , George P. Miljanich
发明人： Alan Justice , Tejinder Singh , Kishor Chandra Gohil , Karen L. Valentino , George P. Miljanich
IPC分类号： A61K38/00 , A61K38/17 , A61P29/00 , C07K14/435 , G01N33/94 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K14/435 , A61K38/17 , C07K14/43504 , G01N33/9486 , G01N2500/00
摘要： A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.
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公开(公告)号：US6136786A
公开(公告)日：2000-10-24
申请号：US392979
申请日：1999-09-09
申请人： Alan Justice , Tejinder Singh , Kishor Chandra Gohil , Karen L. Valentino , George P. Miljanich
发明人： Alan Justice , Tejinder Singh , Kishor Chandra Gohil , Karen L. Valentino , George P. Miljanich
IPC分类号： A61K38/00 , A61K38/17 , A61P29/00 , C07K14/435 , G01N33/94 , A61K39/00 , A61K39/38 , C07K5/00 , C07K7/00
CPC分类号： C07K14/435 , A61K38/17 , C07K14/43504 , G01N33/9486 , G01N2500/00
摘要： A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.
摘要翻译： 公开了一种在伤害性和神经性疼痛中产生止痛的方法。 该方法包括向受试者施用ω-肽，其特征在于其能够（a）抑制电刺激的豚鼠回肠的收缩，和（b）选择性地结合存在于神经元组织中的ω-肽肽MVIIA结合位点。 还公开了有效地产生止痛的新型ω-芋螺毒素肽。
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公开(公告)号：US5994305A
公开(公告)日：1999-11-30
申请号：US138439
申请日：1998-08-21
申请人： Alan Justice , Tejinder Singh , Kishor Chandra Gohil , Karen L. Valentino , George P. Miljanich
发明人： Alan Justice , Tejinder Singh , Kishor Chandra Gohil , Karen L. Valentino , George P. Miljanich
IPC分类号： A61K38/00 , A61K38/17 , A61P29/00 , C07K14/435 , G01N33/94 , C07K7/00 , G01N33/00 , G01N33/48
CPC分类号： C07K14/435 , A61K38/17 , C07K14/43504 , G01N33/9486 , G01N2500/00
摘要： A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.
摘要翻译： 公开了一种在伤害性和神经性疼痛中产生止痛的方法。 该方法包括向受试者施用ω-肽，其特征在于其能够（a）抑制电刺激的豚鼠回肠的收缩，和（b）选择性地结合存在于神经元组织中的ω-肽肽MVIIA结合位点。 还公开了有效地产生止痛的新型ω-芋螺毒素肽。
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公开(公告)号：US6087091A
公开(公告)日：2000-07-11
申请号：US298017
申请日：1999-04-23
申请人： Alan Justice , Tejinder Singh , Kishor Chandra Gohil , Karen L. Valentino , George P. Miljanich
发明人： Alan Justice , Tejinder Singh , Kishor Chandra Gohil , Karen L. Valentino , George P. Miljanich
CPC分类号： C07K14/435 , A61K38/17 , C07K14/43504 , G01N33/9486 , G01N2500/00
摘要： A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.
摘要翻译： 公开了一种在伤害性和神经性疼痛中产生止痛的方法。 该方法包括向受试者施用ω-肽，其特征在于其能够（a）抑制电刺激的豚鼠回肠的收缩，和（b）选择性地结合存在于神经元组织中的ω-肽肽MVIIA结合位点。 还公开了有效地产生止痛的新型ω-芋螺毒素肽。
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公开(公告)号：US5859186A
公开(公告)日：1999-01-12
申请号：US675354
申请日：1996-07-03
申请人： Alan Justice , Tejinder Singh , Kishor Chandra Gohil , Karen L. Valentino , George P. Miljanich
发明人： Alan Justice , Tejinder Singh , Kishor Chandra Gohil , Karen L. Valentino , George P. Miljanich
CPC分类号： C07K14/43504 , A61K38/17 , C07K14/435 , G01N33/9486 , G01N2500/00
摘要： A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.
摘要翻译： 公开了一种在伤害性和神经性疼痛中产生止痛的方法。 该方法包括向受试者施用ω-肽，其特征在于其能够（a）抑制电刺激的豚鼠回肠的收缩，和（b）选择性地结合存在于神经元组织中的ω-肽肽MVIIA结合位点。 还公开了有效地产生止痛的新型ω-芋螺毒素肽。
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公开(公告)号：US5264371A
公开(公告)日：1993-11-23
申请号：US855269
申请日：1992-03-23
申请人： George P. Miljanich , Robert S. Bitner , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Donald H. Yamashiro , Makoto Tsubokawa
发明人： George P. Miljanich , Robert S. Bitner , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Donald H. Yamashiro , Makoto Tsubokawa
IPC分类号： A61K38/00 , C07K14/435 , G01N33/567 , G01N33/68
CPC分类号： C07K14/435 , A61K38/00
摘要： A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.
摘要翻译： 公开了部分纯化的ω-芋螺毒素结合蛋白。 在部分纯化形式或突触体制剂中的蛋白质可用于鉴定在人类患者中用于减少与缺血性疾病如中风有关的神经元损伤的化合物。
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公开(公告)号：US5559095A
公开(公告)日：1996-09-24
申请号：US789913
申请日：1991-11-12
申请人： George P. Miljanich , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Robert S. Bitner , Donald H. Yamashiro
发明人： George P. Miljanich , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Robert S. Bitner , Donald H. Yamashiro
IPC分类号： A61K38/00 , C07K14/435 , A61K38/16
CPC分类号： C07K14/435 , A61K38/00
摘要： A method and compositions for reducing neuronal damage related to an ischemic condition in a mammalian subject are described. The method includes administration of a voltage-gated calcium channel-blocking compound to the subject, 4-24 hours after the onset of the ischemic condition. Such a calcium channel blocking compound is effective to block norepinephrine release in mammalian CNS neuronal cells and is characterized by specific, high affinity binding to omega-conotoxin MVIIA binding sites. Also disclosed are novel peptide structures useful in the treatment method of the invention.
摘要翻译： 描述了用于减少与哺乳动物受试者的缺血状况相关的神经元损伤的方法和组合物。 该方法包括在缺血状态发作后4-24小时向受试者施用电压门控的钙通道阻断化合物。 这种钙通道阻断化合物有效阻断哺乳动物CNS神经细胞中的去甲肾上腺素释放，其特征在于与ω-芋螺毒素MVIIA结合位点的特异性高亲和力结合。 还公开了可用于本发明的治疗方法的新型肽结构。
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公开(公告)号：US5990137A
公开(公告)日：1999-11-23
申请号：US092461
申请日：1998-06-05
IPC分类号： A61K31/136 , A61K31/15 , A61K31/433 , A61K31/444 , A61K31/44 , A61K31/135 , A61K31/41
CPC分类号： A61K31/433 , A61K31/136 , A61K31/15 , A61K31/444
摘要： The instant methods employs pharmaceutical compositions comprising aromatic azines; and imines, of the Formula 1 to selectively inhibit inflammation by preventing the oxidating burst from phagocytic leukocytes caused by NADPH Oxidase.
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