发明授权
- 专利标题： 2-(substituted pyrrolidinylthio) carbapenem derivatives
- 专利标题（中）： 2-（取代的吡咯烷硫基）碳青霉烯衍生物
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申请号： US950717申请日： 1992-09-25
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公开(公告)号： US5373002A公开(公告)日： 1994-12-13
- 发明人: Susumu Nakagawa , Norikazu Ohtake , Fumio Nakano , Koji Yamada , Ryosuke Ushijima , Satoshi Murase , Hiroshi Fukatsu
- 申请人： Susumu Nakagawa , Norikazu Ohtake , Fumio Nakano , Koji Yamada , Ryosuke Ushijima , Satoshi Murase , Hiroshi Fukatsu
- 申请人地址： JPX Tokyo
- 专利权人： Banyu Pharmaceutical Co., Ltd.
- 当前专利权人： Banyu Pharmaceutical Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX2-77431 19900327; JPX2-96654 19900412; JPX2-414637 19901227
- 主分类号： C07D477/20
- IPC分类号： C07D477/20 ; A01N43/00 ; A61K31/395 ; C07D487/04
摘要：
A compound of the formula: ##STR1## wherein R is a hydrogen atom or a methyl group, R.sup.1 is a hydrogen atom or a negative charge, R.sup.2 is a lower alkyl group, a lower alkyl group substituted with a hydroxyl group or --COOR.sup.3 (wherein R.sup.3 is a hydrogen atom or a lower alkyl group), A is .dbd.NH, .dbd.NR.sup.4 or .dbd.N(R.sup.4)R.sup.5 (wherein each of R.sup.4 and R.sup.5 which may be the same or different, is a lower alkyl group or a lower alkyl group substituted with a hydroxyl group), p is an integer of from 0 to 3, and each of q and r which may be the same or different, is an integer of from 0 to 5, provided that q and r are not simultaneously 0 and q +r.ltoreq.6; or a pharmaceutically acceptable salt or ester thereof.
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