Invention Grant
US5403836A Benzazepine platelet aggregation inhibitors having specificity for the
GPII.sub.b III.sub.a receptor
失效
对于GPIIbIIIa受体具有特异性的苯扎西平血小板聚集抑制剂
- Patent Title: Benzazepine platelet aggregation inhibitors having specificity for the GPII.sub.b III.sub.a receptor
- Patent Title (中): 对于GPIIbIIIa受体具有特异性的苯扎西平血小板聚集抑制剂
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Application No.: US58722Application Date: 1993-05-06
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Publication No.: US5403836APublication Date: 1995-04-04
- Inventor: Brent Blackburn , Robert McDowell , Thomas Gadek , Rob Webb
- Applicant: Brent Blackburn , Robert McDowell , Thomas Gadek , Rob Webb
- Applicant Address: CA So. San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: CA So. San Francisco
- Main IPC: A61K31/55
- IPC: A61K31/55 ; A61K31/551 ; A61K31/5513 ; A61K31/5517 ; A61K31/553 ; A61P7/02 ; A61P43/00 ; C07D223/16 ; C07D243/10 ; C07D243/14 ; C07D267/14 ; C07D401/06 ; C07D401/12
Abstract:
A benzazepine derivative that acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
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