发明授权
US5405957A Wavelength-specific photosensitive compounds and expanded porphyrin-like
compounds and methods of use
失效
波长特异性光敏化合物和扩展的卟啉化合物及其使用方法
- 专利标题： Wavelength-specific photosensitive compounds and expanded porphyrin-like compounds and methods of use
- 专利标题（中）： 波长特异性光敏化合物和扩展的卟啉化合物及其使用方法
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申请号： US968966申请日： 1992-10-30
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公开(公告)号： US5405957A公开(公告)日： 1995-04-11
- 发明人: Hang Tang , Lily Xie , Tilak Wijesekera , David Dolphin
- 申请人： Hang Tang , Lily Xie , Tilak Wijesekera , David Dolphin
- 申请人地址： CAX Vancouver
- 专利权人： The University of British Columbia
- 当前专利权人： The University of British Columbia
- 当前专利权人地址： CAX Vancouver
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/409 ; A61K31/555 ; A61K38/00 ; A61K39/395 ; A61K41/00 ; A61K49/06 ; A61K51/00 ; A61K51/04 ; A61P35/00 ; C07B59/00 ; C07D487/22
摘要：
A group of novel expanded porphyrin-like compounds, porphacyanine (Pc) and porphacyanine-like compounds, having absorption maxima in the range of 400-850 nanometers is useful in detecting and treating targeted tissues, cells and viruses. The use of the Pc of the invention permits the irradiation to comprise wavelengths other than those absorbed by blood. The Pc of the invention may also be conjugated to target-specific moieties such as immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits greater depth of treatment penetration and greater specificity in targeting tissues or cells. Coupled with an appropriate paramagnetic ion or radioisotope, the Pc of the invention is suitable for use in nuclear magnetic resonance imaging and radioimaging.
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