Invention Grant
US5409919A Pharmaceutically acceptable salt of
7B-[2-(5-amino-1,2,4-thio-diazol-3-yl)-2(Z)-metho-xyiminoacetamido]-3-[(
imidazo[1,2-b]pyridazinium-1-yl)methyl]-3-cephem-4-carboxylate and
composition comprising same
失效
-3β-[（咪唑并[1,2-b]吡啶-3-基）-2（Z） - 亚氨基亚氨基乙酰氨基] -3 - [（咪唑并[ ]哒嗪鎓-1-基）甲基] -3-头孢烯-4-羧酸钠及其组合物
- Patent Title: Pharmaceutically acceptable salt of 7B-[2-(5-amino-1,2,4-thio-diazol-3-yl)-2(Z)-metho-xyiminoacetamido]-3-[( imidazo[1,2-b]pyridazinium-1-yl)methyl]-3-cephem-4-carboxylate and composition comprising same
- Patent Title (中): -3β-[（咪唑并[1,2-b]吡啶-3-基）-2（Z） - 亚氨基亚氨基乙酰氨基] -3 - [（咪唑并[ ]哒嗪鎓-1-基）甲基] -3-头孢烯-4-羧酸钠及其组合物
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Application No.: US41849Application Date: 1993-04-02
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Publication No.: US5409919APublication Date: 1995-04-25
- Inventor: Akio Miyake , Masahiro Kondo , Masahiko Fujino
- Applicant: Akio Miyake , Masahiro Kondo , Masahiko Fujino
- Applicant Address: JPX Osaka
- Assignee: Takeda Chemical Industries, Ltd.
- Current Assignee: Takeda Chemical Industries, Ltd.
- Current Assignee Address: JPX Osaka
- Priority: NOX851538 19850417; JPX60-209320 19850920
- Main IPC: C07D501/06
- IPC: C07D501/06 ; A61K31/545 ; A61K31/546 ; C07D277/20 ; C07D285/08 ; C07D463/00 ; C07D471/04 ; C07D487/04 ; C07D498/04 ; C07D501/46 ; C07D505/00 ; C07D519/00
Abstract:
A compound of the formula: ##STR1## wherein R.sup.1 is an amino group which may be protected, R.sup.3 is a hydrogen atom or an optionally substituted hydrocarbon residue; Z is S, S.fwdarw.O, O or CH.sub.2, R.sup.4 is a hydrogen atom, methoxy group or formamido group, R.sup.13 is a hydrogen atom, methyl group, hydroxyl group or halogen atom and A.sup..sym. is an optionally substituted imidazolium-1-yl group forming a condensed ring at the 2,3- or 3,4-position or a pharmaceutically acceptable salt or ester thereof is novel and has excellent antibacterial activity.
Public/Granted literature
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