发明授权
US5413935A Process for selecting an enantiomer of a hydroxy lactone using
pseudomonas lipase
失效
使用假单胞菌脂肪酶选择羟基内酯的对映异构体的方法
- 专利标题： Process for selecting an enantiomer of a hydroxy lactone using pseudomonas lipase
- 专利标题（中）： 使用假单胞菌脂肪酶选择羟基内酯的对映异构体的方法
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申请号： US106182申请日： 1993-03-24
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公开(公告)号： US5413935A公开(公告)日： 1995-05-09
- 发明人: Ramesh N. Patel , Clyde G. McNamee , Laszlo J. Szarka
- 申请人： Ramesh N. Patel , Clyde G. McNamee , Laszlo J. Szarka
- 申请人地址： NJ Princeton
- 专利权人： E. R. Squibb & Sons, Inc.
- 当前专利权人： E. R. Squibb & Sons, Inc.
- 当前专利权人地址： NJ Princeton
- 主分类号： C07D405/06
- IPC分类号： C07D405/06 ; C12P17/16 ; C12P41/00
摘要：
An enantiomerically pure compound of the formula ##STR1## is prepared when the associated racemic mixture is reacted with an acrylating agent R.sup.3 --C(O)--O--R in the presence of a microorganism or enzyme derived therefrom capable of catalyzing transesterification of an alcohol. X.sup.1 and X.sup.2 are each independently halogen, R is alkyl, R.sup.1 and R.sup.2 are each independently alkyl, cycloalkyl, aralkyl or aryl and R.sup.3 is alkyl, cycloalkyl, aryl or aralkyl.
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