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公开(公告)号：US06515170B1
公开(公告)日：2003-02-04
申请号：US09843226
申请日：2001-04-26
申请人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Thomas P. Tully , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , William J. Winter , Neal G. Anderson , David A. Lust , Gerard Crispino , Sushil K. Srivastava
发明人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Thomas P. Tully , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , William J. Winter , Neal G. Anderson , David A. Lust , Gerard Crispino , Sushil K. Srivastava
IPC分类号： C07C3200
CPC分类号： C07K5/06139 , A61K38/00 , C07K14/8103 , C12N9/1096
摘要： The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
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公开(公告)号：US6140088A
公开(公告)日：2000-10-31
申请号：US350428
申请日：1999-07-08
申请人： Ronald Hanson , Mary Jo Donovan , Steven Goldberg , Paul A. Jass , Wen-Sen Li , Ramesh Patel , Keith Ramig , Laszlo J. Szarka , John J. Venit
发明人： Ronald Hanson , Mary Jo Donovan , Steven Goldberg , Paul A. Jass , Wen-Sen Li , Ramesh Patel , Keith Ramig , Laszlo J. Szarka , John J. Venit
IPC分类号： C12N15/09 , C12N1/19 , C12N9/06 , C12P7/62 , C12P13/00 , C12P17/04 , C12P17/06 , C12P41/00 , C12R1/01 , C12R1/84 , C12P9/00
CPC分类号： C12N9/0018 , C12P41/002 , C12P41/006 , C12P7/62
摘要： Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
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公开(公告)号：USH1817H
公开(公告)日：1999-11-02
申请号：US734220
申请日：1996-10-21
IPC分类号： C12P19/56
CPC分类号： C12P19/56
摘要： Enzymatic hydrolysis and glycosidation methods for the preparation of pradimicin compounds, especially the compound BMY-28960: ##STR1## and salts thereof.
摘要翻译： 用于制备普拉定霉素化合物，特别是化合物BMY-28960及其盐的酶水解和糖苷化方法。
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4.发明授权Lipase esterification processes for resolution of enantiomeric mixtures of intermediates in the preparation of taxanes 失效用于分离中间体对映异构体混合物在制备紫杉烷中的脂肪酶酯化方法
公开(公告)号：US5811292A
公开(公告)日：1998-09-22
申请号：US691058
申请日：1996-08-01
IPC分类号： C07D205/08 , C07D305/14 , C07D493/00 , C12P13/00 , C12P17/02 , C12P17/10 , C12P41/00 , C12R1/38 , C12R1/39 , C12R1/645 , C12R1/685 , C12R1/72 , C12R1/845 , C12P7/62
CPC分类号： C12P13/001 , C07D205/08 , C07D305/14 , C12P13/02 , C12P17/10 , C12P41/00 , C12P41/004 , C12P41/005 , C07B2200/07
摘要： Methods for the enzymatic resolution of mixtures of enantiomers, such as .beta.-lactam compounds, which may be employed as intermediates in the preparation of taxanes such as taxol, the latter useful in the pharmaceutical field.
摘要翻译： 用于酶拆分对映异构体混合物的方法，例如β-内酰胺化合物，其可用作制备紫杉烷类紫杉醇的中间体，后者可用于制药领域。
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5.发明授权Enzymatic reduction method for the preparation of compounds useful for preparing taxanes 失效用于制备可用于制备紫杉烷类的化合物的酶还原方法
公开(公告)号：US5686298A
公开(公告)日：1997-11-11
申请号：US382455
申请日：1995-02-01
IPC分类号： C07C231/12 , C07C233/87 , C12P7/62
CPC分类号： C07C231/12 , C07C233/87
摘要： An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of compounds useful as intermediates in the preparation of taxanes.
摘要翻译： 一种酶还原方法，特别是立体选择性酶还原方法，用于制备用作制备紫杉烷类的中间体的化合物。
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6.发明授权Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes 失效用于分离用作制备紫杉烷类中间体的化合物的对映体混合物的酶法
公开(公告)号：US5567614A
公开(公告)日：1996-10-22
申请号：US247789
申请日：1994-05-23
IPC分类号： C07D205/08 , C07D305/14 , C07D493/00 , C12P13/00 , C12P17/02 , C12P17/10 , C12P41/00 , C12R1/38 , C12R1/39 , C12R1/645 , C12R1/685 , C12R1/72 , C12R1/845
CPC分类号： C12P13/001 , C07D205/08 , C07D305/14 , C12P13/02 , C12P17/10 , C12P41/00 , C12P41/004 , C12P41/005 , C07B2200/07
摘要： Methods for the enzymatic resolution of mixtures of enantiomers, such as .beta.-lactam compounds, which may be employed as intermediates in the preparation of taxanes such as taxol, the latter useful in the pharmaceutical field.
摘要翻译： 用于酶拆分对映异构体混合物的方法，例如β-内酰胺化合物，其可用作制备紫杉烷类紫杉醇的中间体，后者可用于制药领域。
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公开(公告)号：US5391495A
公开(公告)日：1995-02-21
申请号：US143976
申请日：1993-10-27
IPC分类号： A61K31/18 , A61P9/00 , C07C311/08 , C07C311/21 , C12P13/02 , C12P41/00 , C12R1/01 , C12R1/645 , C12P7/22 , C12N1/14 , C12N1/20
CPC分类号： C07C311/08 , C07C311/21 , C12P13/02 , Y10S435/872 , Y10S435/911 , Y10S435/931
摘要： The present invention concerns a process for the stereoselective enzymatic reduction of keto group-containing compounds such as N-(4-(2-chloroacetyl)phenyl)methanesulfonamido to form the corresponding hydroxyl-group containing compound. The process is selective for the D(+) enantiomer and is catalyzed by enzymes such as oxido-reductase or dehydrogense, or by microorganisms such as Hansenula, Rhodococcus, or Norcardia species.
摘要翻译： 本发明涉及用于立体选择性酶还原含酮基化合物如N-（4-（2-氯乙酰基）苯基）甲磺酰氨基的方法，以形成相应的含羟基化合物。 该方法对D（+）对映异构体是选择性的，并且被酶例如氧化还原酶或脱氢酶或由诸如汉逊酵母（Hansenula），红球菌属（Rhodococcus）或诺卡氏菌（Norcardia）等微生物催化。
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8.发明授权
公开(公告)号：US4981794A
公开(公告)日：1991-01-01
申请号：US110166
申请日：1987-10-19
IPC分类号： C12P7/42
CPC分类号： C12P7/42 , Y10S435/911 , Y10S435/922
摘要： A method is provided for preparing D(-)-.beta.-hydroxyisobutyric acid by fermentation employing the method and/or ethyl esters of isobutyric acid, the methyl and/or ethyl esters of methacrylic acid, isobutyl isobutyrate and/or isobutyl methacrylate as the substrate and a microorganism of the genus Candida and other fungi. In an alternative method, the isolated cells of the various microorganisms are employed with one or mixtures of the above substrates.
摘要翻译： 提供了通过使用异丁酸的方法和/或乙酯的发酵制备D（ - ） - β-羟基异丁酸的方法，甲基丙烯酸的甲基和/或乙基酯，异丁酸异丁酯和/或甲基丙烯酸异丁酯作为底物 以及假丝酵母属和其他真菌属的微生物。 在另一种方法中，各种微生物的分离的细胞与上述底物的一种或混合物一起使用。
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公开(公告)号：US5986095A
公开(公告)日：1999-11-16
申请号：US817232
申请日：1992-01-06
IPC分类号： C07C29/09 , C07D239/42 , C07D403/04
CPC分类号： C07D239/42 , C07C29/095 , C07B2200/07
摘要： A process is described for preparing a compound of the formula or the S-enantiomer thereof,wherein:R is alkyl, aryl, cycloalkyl, aralkyl, or cycloalkylalkyl,R.sup.1 is halogen;R.sup.2 is halogen, alkyl, cycloalkyl, aryl or ##STR1## wherein the process comprises treating the associated racemic alcohol with an acylatingagent ##STR2## (wherein L is a leaving group) and an enzyme or microorganism capable of enantioselective acylation. This process may also be used to isolate the unreacted R- or S-alcohol. The acylated product may be enantioselectively hydrolyzed with a lipase or lipase-supplying microorganism to the S- or R-alcohol. Compounds prepared by this invention are useful antipsychotic agents or useful intermediates therefor.
摘要翻译： 描述了制备下式化合物或其S-对映异构体的方法，其中：R是烷基，芳基，环烷基，芳烷基或环烷基烷基，R 1是卤素; R 2是卤素，烷基，环烷基，芳基或其中所述方法包括用酰化剂（其中L是离去基团）和能够进行对映选择性酰化的酶或微生物处理相关的外消旋醇。 该方法也可用于分离未反应的R-或S-醇。 酰化产物可以用脂肪酶或脂肪酶供应微生物对映选择性地水解成S-或R-醇。 通过本发明制备的化合物是有用的抗精神病药或其有用的中间体。
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10.发明授权Method of chiral epoxidation of benzopyran or pyranopyridine derivatives using microorganisms 失效使用微生物手性环氧化苯并吡喃或吡喃并吡啶衍生物的方法
公开(公告)号：US5478734A
公开(公告)日：1995-12-26
申请号：US192918
申请日：1994-02-07
IPC分类号： C07D311/22 , C07D311/70 , C07D493/04 , C12P17/18 , C12P41/00 , C12P17/06
CPC分类号： C07D493/04 , C07D311/22 , C07D311/70 , C12P17/18 , C12P17/181 , C12P41/004
摘要： An enzymatic process for the preparation of chiral epoxides, monohydroxy or dihydroxy compounds of formula ##STR1## by the stereoselective epoxidation or hydroxylation of benzopyrans of formula ##STR2## or resolution of compounds of formula ##STR3## The compounds of formula I and II are intermediates useful in the preparation of pyranyl cyanoguanidine derivatives.
摘要翻译： 通过式III的苯并吡喃的立体选择性环氧化或羟基化或通式IIa的化合物的拆分来制备式I化合物的手性环氧化物，单羟基或二羟基化合物的酶促方法化合物 式I和II是可用于制备吡喃基氰胍衍生物的中间体。
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