发明授权
- 专利标题: Preparation of 4-methylpyrimidines
- 专利标题(中): 4-甲基嘧啶的制备
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申请号: US199452申请日: 1994-02-22
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公开(公告)号: US5414086A公开(公告)日: 1995-05-09
- 发明人: Stefan Rittinger , Norbert Rieber
- 申请人: Stefan Rittinger , Norbert Rieber
- 申请人地址: DEX Ludwigshafen
- 专利权人: BASF Aktiengesellschaft
- 当前专利权人: BASF Aktiengesellschaft
- 当前专利权人地址: DEX Ludwigshafen
- 优先权: DEX4308073.1 19930313
- 主分类号: C07D239/26
- IPC分类号: C07D239/26 ; C07D239/42 ; C07D295/104 ; C07D239/34 ; C07D239/38
摘要:
A process for the preparation of a 4-methylpyrimidine of the general formula I ##STR1## in which R.sup.1 denotes C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.12 phenalkyl, C.sub.7 -C.sub.12 alkylphenyl, NH.sub.2, NHCN, OH, and SH,in which a 1-aminovinyl methyl ketone of the general formula II ##STR2## in which R.sup.2 and R.sup.3 denote C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.12 phenylalkyl, C.sub.7 -C.sub.12 alkylphenyl, C.sub.1 -C.sub.20 hydroxyalkyl or together denote a C.sub.2 -C.sub.7 alkylene chain optionally mono- to tetra-substituted by C.sub.1 -C.sub.4 alkyl and optionally interrupted by oxygen, nitrogen, or sulfur, is caused to react with a carboxamide or amidine or a salt thereof of the general formula III ##STR3## in which R.sup.1 has the aforementioned meanings and x stands for oxygen or NH, at temperatures ranging from 20.degree. to 200.degree. C. and pressures ranging from 0.01 to 50 bar.