发明授权
- 专利标题： Mammalian DNA topoisomerase II inhibitor and method
- 专利标题（中）： 哺乳动物DNA拓扑异构酶II抑制剂和方法
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申请号： US32867申请日： 1993-03-18
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公开(公告)号： US5426224A公开(公告)日： 1995-06-20
- 发明人: Kuo-Hsiung Lee , Kenneth F. Bastow
- 申请人： Kuo-Hsiung Lee , Kenneth F. Bastow
- 申请人地址： NC Chapel Hill
- 专利权人： The University of North Carolina at Chapel Hill
- 当前专利权人： The University of North Carolina at Chapel Hill
- 当前专利权人地址： NC Chapel Hill
- 主分类号： C07C233/32
- IPC分类号： C07C233/32 ; C07C233/76 ; C07C233/65
摘要：
A novel antiproliferative drug and methods are disclosed. The drug has the general structural formula: ##STR1## where R1=OR.sub.1 ', SR.sub.1 ', or N(R.sub.1 'R.sub.1 ").sub.2, where R.sub.1 ' and R.sub.1 " are H or lower alkyl groups, and R.sub.2 is an acylamino, or aroylamino group. The compound is useful for inhibiting cell proliferation in drug-resistant tumor cells. Also disclosed is a method of chemical converting a colchicine derivative to form an active inhibitor of DNA topisomerase II.
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