An open-end spinning machine with a machine frame with at least one section. The latter is provided for each longitudinal machine side with a rigid structural unit which consists of several longitudinal structural elements and two end walls. Intermediate walls are provided at least between two adjoining pairs of spinning stations. These intermediate walls are rigidly connected to the longitudinal structural elements as are the intermediate walls, whereby the groups of technological spinning elements, including the parts of drive units and the winding mechanisms are attached to longitudinal structural elements and/or to the intermediate walls. The end walls of the two structural units are connected to each other in pairs.