发明授权
- 专利标题： Process for the preparation of binary indole alkaloids
- 专利标题（中）： 二元吲哚生物碱的制备方法
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申请号： US55788申请日： 1993-05-03
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公开(公告)号： US5432279A公开(公告)日： 1995-07-11
- 发明人: Naoya Sakamoto , Hiroaki Tan , Eiichirou Hata , Noriaki Kihara
- 申请人： Naoya Sakamoto , Hiroaki Tan , Eiichirou Hata , Noriaki Kihara
- 申请人地址： JPX Tokyo
- 专利权人： Mitsui Petrochemical Industries, Inc.
- 当前专利权人： Mitsui Petrochemical Industries, Inc.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX1-50988 19890304; JPX1-50989 19890304; JPX1-50990 19890304; JPX1-50991 19890304; JPX1-194306 19890728; JPX1-231659 19890908; JPX1-284966 19891102
- 主分类号： C07D519/04
- IPC分类号： C07D519/04
摘要：
The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.
公开/授权文献
- US5949365A Multiple-beam radar system 公开/授权日：1999-09-07