发明授权
- 专利标题： Hydroisoquinoline derivatives
- 专利标题（中）： 氢异喹啉衍生物
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申请号： US175371申请日： 1994-01-05
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公开(公告)号： US5441956A公开(公告)日： 1995-08-15
- 发明人: Vittorio Vecchietti , Giulio Dondio , Silvano Ronzoni , Roberto Colle
- 申请人： Vittorio Vecchietti , Giulio Dondio , Silvano Ronzoni , Roberto Colle
- 申请人地址： ITX Milan
- 专利权人： Smithkline Beecham Farmaceutici S.p.A.
- 当前专利权人： Smithkline Beecham Farmaceutici S.p.A.
- 当前专利权人地址： ITX Milan
- 优先权： ITXMI91A1863 19910705; ITXMI92A0563 19920311
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61K31/475 ; A61P25/04 ; C07D471/04 ; C07D491/04 ; C07D491/048 ; C07D495/04 ; A61K31/495
摘要：
##STR1## Compounds of formula (I) in which, R is linear or branched alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl or furan-2-yl alkyl; R
1 and R
2 , which may be the same or different, are each hydrogen, hydroxy, alkoxy, or halogen; R
3 is hydrogen, hydroxy or alkoxy; "Het" is optionally substituted single or fused heteroxyclic ring, containing from 5 to 10 ring atoms and comprising up to four heteratoms in the or each ring, selected from oxygen, nitrogen and sulphur; R
4 and R
5 , which may be the same or different, are each hydrogen alkyl, halogen, nitro; CF, cyano, alkoxy carbonyl, NH, alkylcarbonylamino, hydroxy, alkoxy, or benzyl, are selective delta receptor agonists and are useful in the treatment of pain.
1 and R
2 , which may be the same or different, are each hydrogen, hydroxy, alkoxy, or halogen; R
3 is hydrogen, hydroxy or alkoxy; "Het" is optionally substituted single or fused heteroxyclic ring, containing from 5 to 10 ring atoms and comprising up to four heteratoms in the or each ring, selected from oxygen, nitrogen and sulphur; R
4 and R
5 , which may be the same or different, are each hydrogen alkyl, halogen, nitro; CF, cyano, alkoxy carbonyl, NH, alkylcarbonylamino, hydroxy, alkoxy, or benzyl, are selective delta receptor agonists and are useful in the treatment of pain.
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