发明授权
US5449750A Prolyl endopeptidase inhibitors SNA-115 and SNA-115T, and process for
the production and productive strain thereof
失效
脯氨酰内肽酶抑制剂SNA-115和SNA-115T，以及其生产和生产应变的方法
- 专利标题： Prolyl endopeptidase inhibitors SNA-115 and SNA-115T, and process for the production and productive strain thereof
- 专利标题（中）： 脯氨酰内肽酶抑制剂SNA-115和SNA-115T，以及其生产和生产应变的方法
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申请号： US977444申请日： 1993-02-17
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公开(公告)号： US5449750A公开(公告)日： 1995-09-12
- 发明人: Kenichi Kimura , Fumiko Kanou , Hidetoshi Takahashi , Kazuhiko Kurosawa , Makoto Yoshihama
- 申请人： Kenichi Kimura , Fumiko Kanou , Hidetoshi Takahashi , Kazuhiko Kurosawa , Makoto Yoshihama
- 申请人地址： JPX Hokkaido
- 专利权人： Snow Brand Milk Products Co., Ltd.
- 当前专利权人： Snow Brand Milk Products Co., Ltd.
- 当前专利权人地址： JPX Hokkaido
- 优先权： JPX3-176228 19910620; JPX4-078262 19920228
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K7/56 ; C12P21/04 ; C07K7/64 ; A61K38/12 ; C07K7/08
摘要：
Prolyl endopeptidase inhibiting compounds SNA-115 and SNA-115T are provided having molecular formulas of C.sub.113 H.sub.142 N.sub.26 O.sub.27 and C.sub.113 H.sub.144 N.sub.26 O.sub.28 respectively. SNA-115T has the following structural formula:Arg Tyr Asp Trp Trp Pro Tyr Gly Asp Leu Phe Gly Gly His Thr Phe Ile Ser ProProcesses are also provided for the production of SNA-11 by culturing the SNA productive microorganism and production of SNA-115T by degradation of SNA-115 with trypsin. Both SNA-115 and SNA-115T exhibit prolyl endopeptidase inhibitory properties.
公开/授权文献
- US6015170A Coupling assembly 公开/授权日：2000-01-18
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