发明授权
US5451399A [ALA IL-8].sub.77 and [SER IL-8].sub.72 as Leukocyte adhesion inhibitors
失效
[ALA IL-8] 77和[SER IL-8] 72作为白细胞粘附抑制剂
- 专利标题： [ALA IL-8].sub.77 and [SER IL-8].sub.72 as Leukocyte adhesion inhibitors
- 专利标题（中）： [ALA IL-8] 77和[SER IL-8] 72作为白细胞粘附抑制剂
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申请号： US964525申请日： 1992-10-19
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公开(公告)号： US5451399A公开(公告)日： 1995-09-19
- 发明人: Michael A. Gimbrone, Jr. , Martin S. Obin , Joffre B. Baker , Caroline A. Hebert
- 申请人： Michael A. Gimbrone, Jr. , Martin S. Obin , Joffre B. Baker , Caroline A. Hebert
- 申请人地址： MA Boston CA South San Francisco
- 专利权人： Brigham and Women's Hospital,Genentech, Inc.
- 当前专利权人： Brigham and Women's Hospital,Genentech, Inc.
- 当前专利权人地址： MA Boston CA South San Francisco
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P29/00 ; C07K14/00 ; C07K14/52 ; C07K14/54 ; C07K19/00 ; C12N1/21 ; C12N5/10 ; C12N15/09 ; C12N15/24 ; C12P21/02 ; C12R1/19 ; C12R1/91 ; A61K45/05 ; A61K38/16
摘要：
A novel polypeptide [Ala IL-8].sub.77 is provided which is a potent modulator of neutrophil functions. The polypeptide factor and related compositions find use as anti-inflammatory agents and as therapeutics for clinical indications in which damage to vascular endothelium and other tissues occurs. The amino acid and nucleotide sequence of the factor and methods for its purification, recombinant production and pharmaceutical use are provided.
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