发明授权
US5464832A Substituted 3-thioacryloyl compounds and their use as antimicrobial
agents
失效
取代的3-硫代丙烯酰化合物及其作为抗微生物剂的用途
- 专利标题: Substituted 3-thioacryloyl compounds and their use as antimicrobial agents
- 专利标题(中): 取代的3-硫代丙烯酰化合物及其作为抗微生物剂的用途
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申请号: US166498申请日: 1993-12-13
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公开(公告)号: US5464832A公开(公告)日: 1995-11-07
- 发明人: Peter Osei-Gyimah , Samuel E. Sherba , Barry C. Lange , Rai J. Mehta , Rhoda W. Joseph
- 申请人: Peter Osei-Gyimah , Samuel E. Sherba , Barry C. Lange , Rai J. Mehta , Rhoda W. Joseph
- 申请人地址: PA Philadelphia
- 专利权人: Rohm and Haas Company
- 当前专利权人: Rohm and Haas Company
- 当前专利权人地址: PA Philadelphia
- 主分类号: A01N37/36
- IPC分类号: A01N37/36 ; A01N41/12 ; A01N43/10 ; A01N43/40 ; A01N43/50 ; A01N43/713 ; A01N43/78 ; A01N47/42 ; A01N47/48 ; C07C323/54 ; C07C323/60 ; C07C331/14 ; C07C335/32 ; C07D213/70 ; C07D213/89 ; C07D233/42 ; C07D257/04 ; C07D277/36 ; C07D277/74 ; C07D333/28 ; C07D211/06 ; A61K31/535 ; C07D263/04 ; C07D265/30
摘要:
A thioacryloyl compound of the formula ##STR1## wherein Z is selected from the group consisting of OR, R and NR.sup.1 R.sup.2 ;R is selected from the group consisting of hydrogen; (C.sub.1 -C.sub.18)alkyl; (C.sub.1 -C.sub.8)alkenyl; (C.sub.1 -C.sub.8)haloalkynyl; 2-(5-chlorothienyl)methyl; phenyl optionally substituted with one or more substituents selected from the group consisting of halo-, (C.sub.1 -C.sub.3)alkoxy-, nitro-, and (C.sub.1 -C.sub.3)alkyl; phenacyl optionally substituted with one or more substituents selected from the group consisting of ring halo-, (C.sub.1 -C.sub.3)alkoxy-, nitro-, and (C.sub.1 -C.sub.3)alkyl; arylalkyl optionally substituted with one or more substituents selected from the group consisting of ring halo-, (C.sub.1 -C.sub.3)alkoxy-, nitro-, and (C.sub.1 -C.sub.3)alkyl;R.sup.1 and R.sup.2 are independently selected from (C.sub.1 -C.sub.8)alkyl and phenyl, or R.sup.1 and R.sup.2 may be joined together with the nitrogen atom to which they are attached to form a ring containing 4 to 5 carbon atoms with or without an oxygen heteroatom;X is selected from the group consisting of hydrogen, halogen, phenyl, CO.sub.2 CH.sub.3, and (C.sub.1 -C.sub.3)alkyl; andY is selected from the group consisting of CN, CH(COCH.sub.3).sub.2, CH.sub.2 COCH.sub.3, CH.sub.2 CN, CH.sub.2 CO.sub.2 C.sub.2 H.sub.5 -propargyl, SCH.dbd.CHCO.sub.2 CH.sub.3, C(.dbd.NH)NH.sub.2 hydrochloride, and 2-(5-chlorothienyl)methyl;provided that when Z is NR.sup.1 R.sup.2, Y is CN; andprovided that when Z is R, X is hydrogen, and Y is CN, R is not phenyl.
公开/授权文献
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