发明授权
- 专利标题: Method for recovering L-phenylalanine
- 专利标题(中): L-苯丙氨酸的回收方法
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申请号: US190450申请日: 1994-02-02
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公开(公告)号: US5466864A公开(公告)日: 1995-11-14
- 发明人: Tadashi Takemoto , Toyoto Hijiya , Teruo Yonekawa , Chiaki Mochizuki
- 申请人: Tadashi Takemoto , Toyoto Hijiya , Teruo Yonekawa , Chiaki Mochizuki
- 申请人地址: JPX Tokyo
- 专利权人: Ajinomoto Co., Inc.
- 当前专利权人: Ajinomoto Co., Inc.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX5-036880 19930225; JPX5-036881 19930225; JPX5-061972 19930322
- 主分类号: C07C227/40
- IPC分类号: C07C227/40 ; C07C227/42 ; C07C229/36 ; C07C53/134
摘要:
The present invention provides crystals of L-phenylalanine monomethyl sulfate which have low solubility compared to L-tyrosine and D-phenylalanine. The L-phenylalanine monomethylsulfate crystals are obtained by subjecting a solution containing monomethyl sulfuric acid and phenylalanine to crystallization.Further, the present invention also provides a process for recovering L-phenylalanine from a water layer by neutralizing the esterified reaction, extracting an ester of L-phenylalanine therefrom with an organic solvent, and recovering remaining L-phenylalanine in the water layer as L-phenylalanine monomethylsulfate. L-phenylalanine monomethyl sulfate is obtained by esterifying L-phenylalanine and methanol in the presence of sulfuric acid, neutralizing the esterified solution with a base in the presence of water, extracting the produced L-phenylalanine methyl ester from the neutralized solution with an organic solvent, and then crystallized the resultant water layer under acidic condition.