公开(公告)号：US20250034079A1

公开(公告)日：2025-01-30

申请号：US18716262

申请日：2022-12-16

Applicant: Covestro Deutschland AG

Inventor： Jonas Krause ,  Maria Francisco Casal ,  Wolf Kloeckner ,  Andreas Bednarz

IPC: C07C227/42 ,  C07C227/16

Abstract: The present invention relates to a process for recovering aminobenzoic acid from an aqueous mother liquor which is produced on crystallization of aminobenzoic acid. The process comprises a step (A) of fermenting a suitable fermentable raw material in the presence of microorganisms to form aminobenzoate anions and/or aminobenzoic acid; a step (B) of crystallising aminobenzoic acid at a pH of 3.0 to 4.7, wherein this crystallisation can be carried out during and/or after the fermentation; a step (C) of extracting the aqueous mother liquor of the crystallisation using an alkanol with 8 to 12 carbon atoms to obtain a first alcoholic phase containing aminobenzoic acid and a first aqueous phase; a step (D) of back-extracting aminobenzoic acid from the first alcoholic phase using an aqueous base solution or acid solution to obtain a second aqueous phase containing anions and cations of the aminobenzoic acid and a second alcoholic phase; and a step (E) of crystallising aminobenzoic acid from the second aqueous phase by feeding the latter back into the crystallisation of step (B) or in a separate crystallisation.

公开(公告)号：US20240158423A1

公开(公告)日：2024-05-16

申请号：US18279989

申请日：2022-03-02

Applicant: MONSANTO TECHNOLOGY LLC

Inventor： Justin Robert STRUBLE ,  Jian XU

IPC: C07F9/38 ,  C07C227/18 ,  C07C227/42

CPC classification number: C07F9/3813 ,  C07C227/18 ,  C07C227/42

Abstract: This disclosure relates to an improved electrodialysis method for preparing an amino acid (e.g., iminodiacetic acid) from a salt of the amino acid (e.g., disodium iminodiacetic acid) utilizing a two-compartment bipolar membrane electrodialysis process wherein at least a portion of the salt product stream comprising the amino acid and one or more salt thereof is recirculated to the two-compartment bipolar membrane. The process also comprises removing at least a portion of the recirculation stream and phosphonomethylating the amino acid therein. The process further comprises recovering a base product stream and utilizing the base product stream for preparing the salt of the amino acid.

公开(公告)号：US20240140906A1

公开(公告)日：2024-05-02

申请号：US18279902

申请日：2022-03-01

Applicant: BASF SE

Inventor： Daniel Ruben SELZER ,  Eva KLEINMANN ,  Axel BINDER ,  Helmut KRONEMAYER ,  Philipp STAEHLE

IPC: C07C227/42 ,  B01D9/00

CPC classification number: C07C227/42 ,  B01D9/0036

Abstract: The present invention relates to a process for the solidification of hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI diethylamino hydroxybenzoyl hexyl benzoate, DHHB), wherein the process comprises the step of (a) applying a shear rate of less than 800 s−1 to liquid hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate and (b) adding seed crystals of hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate.

公开(公告)号：US20230365492A1

公开(公告)日：2023-11-16

申请号：US18328801

申请日：2023-06-05

Applicant: ANYU BIOTECHNOLOGY (HANGZHOU) CO., LTD.

Inventor： TAN, Jun ,  CHEN, Binhui ,  LI, SONG ,  TANG, QINMIN ,  CHEN, JIANG

IPC: C07C227/14 ,  C07F1/02 ,  C12P13/24 ,  C07C227/42

CPC classification number: C07C227/14 ,  C07F1/02 ,  C12P13/24 ,  C07C227/42

Abstract: The present invention discloses a lithium organic acid-amino acid salt. A lithium organic acid is one or more of lithium isobutyrate, lithium n-butyrate, lithium lactate, lithium citrate or lithium cholesterol; an amino acid is one of L-proline, valine, lysine or artificially synthetic amino acids; and the lithium organic acid-amino acid salt is a salt formed by the lithium organic acid and the amino acid. The present invention further discloses a crystal form, a preparation method and an application of the salt. The lithium organic acid-amino acid salt of the present invention has a positive curative effect and a preventive effect on recurrent episodes of mania and depression in bipolar disorder, and can delay degenerative changes of the central nervous system to realize better distribution in the central nervous system.

公开(公告)号：US20230115605A1

公开(公告)日：2023-04-13

申请号：US17912142

申请日：2021-03-02

Applicant: GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

Inventor： Yuguang WANG ,  Nong ZHANG ,  Pingjing ZHANG

IPC: C07C229/22 ,  C07C227/42

Abstract: Disclosed in the present invention are a crystal form of aromatic vinyl derivatives, and a preparation method therefor and the use thereof. Specifically disclosed in the present invention are crystal form A, crystal form B and crystal form C of a compound as shown in formula I. The crystal forms of the present invention have a good stability, are less hygroscopic and are easy to prepare, and have an important value in terms of the optimization and development of drugs.

公开(公告)号：US10766014B2

公开(公告)日：2020-09-08

申请号：US15496355

申请日：2017-04-25

Applicant: Purdue Research Foundation

Inventor： Andy Koswara ,  Zoltan Kalman Nagy

IPC: C30B29/54 ,  B01J19/00 ,  C07C227/42 ,  C07C231/24 ,  B08B7/00 ,  B08B17/00 ,  C30B7/08 ,  B01D9/00

Abstract: The invention generally relates to systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer. In certain aspects, the invention provides a system that includes a plug flow crystallizer having a channel, one or more heating/cooling elements, each operably associated with a different segment of the channel, and a controller. The controller is operably coupled to the one or more heating/cooling elements and configured to implement a temperature profile within the channel of the plug flow crystallizer that grows crystals in a plug of fluid that flows through a first segment of the channel and dissolves encrust in a second segment of the channel while having minimal impact on crystal growth in the plug of fluid in the second segment of the channel. In certain embodiments, these segments may be cyclically alternated, in that the segment in which crystal grows in one cycle becomes the segment in which crystal dissolves in the next cycle and vice versa, to realize a fully continuous crystallization process.

公开(公告)号：US10421711B2

公开(公告)日：2019-09-24

申请号：US16061007

申请日：2016-12-07

Applicant: BASF SE

Inventor： Constanze Franzke ,  Axel Franzke ,  Armin Stamm ,  Markus Hartmann ,  Robert Baumann

IPC: C07C227/10 ,  C07C227/18 ,  C07C227/42 ,  C07C227/02 ,  C07C229/36 ,  C11D3/33

Abstract: Process for manufacturing a crystalline alkali metal salt of the general formula (I) [R1—CH(COO)—N(CH2—COO)2]M13 (I) wherein M1 is selected from alkali metal cations, same or different, R1 is selected from C1-C4-alkyl and CH2CH2COOM1, comprising the step of (b) crystallizing said alkali metal salt from an aqueous solution containing in the range of from 5 to 30% by weight of alkali metal hydroxide, referring to said aqueous solution.

公开(公告)号：US10329240B2

公开(公告)日：2019-06-25

申请号：US15644665

申请日：2017-07-07

Applicant: VITAWORKS IP, LLC

Inventor： Songzhou Hu

IPC: C07C227/42 ,  C07C227/40 ,  C07C51/44 ,  C07C51/43 ,  C07C209/86 ,  B01D3/36 ,  B01D9/00 ,  B01D11/04 ,  C07C51/46 ,  C07C51/47 ,  C07C51/48 ,  B01D21/26

Abstract: There is disclosed a process for the separation of long chain amino acid and long chain dibasic acid, comprising: (1) recovering alkylamine from an aqueous solution of an alkali hydroxide hydrolysis of the mixed amide derivatives by distilling or by extracting with an extractant solvent; (2) cooling the aqueous solution of step (1) to precipitate a mixed alkali salts of long chain amino acid and dibasic acid; (3) recovering the mixed alkali salts of long chain amino acid and dibasic acid to provide a mother liquor; (4) separating long chain amino acid and dibasic acid by acidification-extraction of long chain dibasic acid with an extractant solvent or by selective dissolution of alkali salt of long chain amino acid in an aqueous solvent; and (4) adding an acid to the mother liquor of step (3) to obtain alkanoic acid.

公开(公告)号：US10239823B2

公开(公告)日：2019-03-26

申请号：US15686500

申请日：2017-08-25

Applicant: VITAWORKS IP, LLC

Inventor： Songzhou Hu ,  William S. Hu

IPC: C07C227/40 ,  C07C227/42

Abstract: There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the absence or presence of solvent, comprising: (1) dissolving a long chain amino acid in an aqueous solution of organic carboxylic acid by heating; (2) cooling the solution of step (1) to crystallize the long chain amino acid; and (3) recovering the long chain amino acid of step (2) by means of solid-liquid separation.

公开(公告)号：US10173964B2

公开(公告)日：2019-01-08

申请号：US15469359

申请日：2017-03-24

Applicant: OCERA THERAPEUTICS, INC.

Inventor： Keith E. Anderson ,  Jim Behling ,  Christine Henderson Dougan ,  Stephen William Watt ,  Peter Manini ,  Attilia Figini

IPC: C07C57/32 ,  A61K31/205 ,  C07C227/40 ,  A61K31/192 ,  A61K31/198 ,  C07C229/26 ,  C07C227/42 ,  C07C51/42

Abstract: Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.