发明授权
- 专利标题： Method for culturing T precursor cells under conditions of high oxygen concentration
- 专利标题（中）： 在高氧浓度条件下培养T前体细胞的方法
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申请号： US983514申请日： 1993-03-04
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公开(公告)号： US5476780A公开(公告)日： 1995-12-19
- 发明人: Yoshihiro Watanabe
- 申请人： Yoshihiro Watanabe
- 申请人地址： JPX Tokyo
- 专利权人： Japan Tobacco, Inc.
- 当前专利权人： Japan Tobacco, Inc.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX3-258283 19910704
- 主分类号： C12N5/0783
- IPC分类号： C12N5/0783 ; C12N5/00
摘要：
The present invention provides culture methods of T lineage precursor cells comprising a step of culturing the T lineage precursor cells under a condition that a dissolved oxygen concentration in the nutrient medium is higher than a dissolved oxygen concentration in the nutrient medium when the medium is in contact with normal atmospheric air.According to the methods of the present invention, by using a submerged (suspension) culture which is a general method for culturing cells or tissues, the derivation of matured T cell(s) differentiated from T precursor cells in terms of their phenotypes of differentiation antigens and of their functions is realized to be accomplished.
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