发明授权
US5480864A Modified maxadilan protein, its preparation and use, and DNA encoding
the protein
失效
修饰的maxadilan蛋白,其制备和使用,以及编码蛋白质的DNA
- 专利标题: Modified maxadilan protein, its preparation and use, and DNA encoding the protein
- 专利标题(中): 修饰的maxadilan蛋白,其制备和使用,以及编码蛋白质的DNA
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申请号: US102757申请日: 1993-08-06
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公开(公告)号: US5480864A公开(公告)日: 1996-01-02
- 发明人: Masahiro Tajima , Manami Ohnuma , Ethan L. Lerner
- 申请人: Masahiro Tajima , Manami Ohnuma , Ethan L. Lerner
- 申请人地址: JPX MA
- 专利权人: Shiseido Co., Ltd.,The General Hospital
- 当前专利权人: Shiseido Co., Ltd.,The General Hospital
- 当前专利权人地址: JPX MA
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; A61K38/00 ; A61P9/08 ; C07H21/04 ; C07K14/435 ; C12N1/21 ; C12N15/12 ; C12P21/02 ; C12R1/19 ; C07H19/00 ; C12N9/48 ; C12P21/06
摘要:
A modified maxadilan protein exhibits higher biological activity than native maxadilan from the sand fly Lutzomyia longipalpis. A modified maxadilan fusion protein contains a thrombin cleavage site. This enables the production of the modified maxadilan as a fusion protein and recovery of the modified maxadilan after digestion with thrombin. The modified maxadilan is a potent vasodilator.
公开/授权文献
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