发明授权
- 专利标题: Penem derivatives
- 专利标题(中): Penem衍生物
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申请号: US972444申请日: 1993-04-09
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公开(公告)号: US5480880A公开(公告)日: 1996-01-02
- 发明人: Giuseppina Visentin , Franco Zarini , Daniela Jabes , Ettore Perrone , Costantino della Bruna , Marco Alpegiani
- 申请人: Giuseppina Visentin , Franco Zarini , Daniela Jabes , Ettore Perrone , Costantino della Bruna , Marco Alpegiani
- 申请人地址: ITX Milan
- 专利权人: Farmitalia Carlo Erba S.r.l.
- 当前专利权人: Farmitalia Carlo Erba S.r.l.
- 当前专利权人地址: ITX Milan
- 优先权: GBX9113427 19910621
- 主分类号: A61K31/43
- IPC分类号: A61K31/43 ; A61K31/431 ; A61K31/44 ; A61K31/675 ; A61P31/04 ; C07D499/88 ; C07D499/883 ; C07D499/893 ; C07D499/897 ; C07D499/00
摘要:
The invention provides compounds of the general formula I ##STR1## wherein R.sub.1 is a hydrogen atom, a negative charge or an ester residue; R is:a) --(CH.sub.2).sub.n --A--CO.sub.2 H, --(CH.sub.2)n--A--SO.sub.3 H or --(CH.sub.2).sub.n --A--PO.sub.3 H.sub.2, wherein n is either zero, one or two and A is a group --CH.dbd.CH-- (either E or Z), --OCH.sub.2 --, --SCH.sub.2 -- or --CHOH--;b) --(CH.sub.2).sub.n --PO.sub.3 H.sub.2, --(CH.sub.2).sub.n SO.sub.2 NHCN, --(CH.sub.2).sub.n NHSO.sub.3 H, --(CH.sub.2).sub.n CONHSO.sub.2 CH.sub.3 or --(CH.sub.2).sub.n CONHSO.sub.2 CF.sub.3, wherein n is as defined above;c) --(CH.sub.2 S).sub.m --W--(CH.sub.2).sub.n Z, wherein W is an arylene group or a heterocyclediyl group, m is 0 or 1, n is as above defined, and Z represents CO.sub.2 H, PO.sub.3 H.sub.2, SO.sub.2 NHCN, NHSO.sub.3 H, CONHSO.sub.2 CH.sub.3 or CONHSO.sub.2 CF.sub.3 ;d) ##STR2## wherein Y is O or NH and X is NH, N--OH or N--O--(CH.sub.2).sub.n+1 COOH wherein n is as defined above; ore) --(CH.sub.2 S).sub.m --W', wherein W' is a heterocyclyl group convertible into an anion at physiological pH and m is as defined above.Compounds I, their salts and ester prodrugs have antibacterial activity.
公开/授权文献
- US6091655A Semiconductor memory 公开/授权日:2000-07-18