Invention Grant
US5495005A Synthesis and pharmacological activity of a series of novel xanthone
derivatives
失效
一系列新型呫吨酮衍生物的合成和药理活性
- Patent Title: Synthesis and pharmacological activity of a series of novel xanthone derivatives
- Patent Title (中): 一系列新型呫吨酮衍生物的合成和药理活性
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Application No.: US112704Application Date: 1993-08-26
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Publication No.: US5495005APublication Date: 1996-02-27
- Inventor: Chun-Nan Lin , Che-Ming Teng , Ing-Jun Chen , Shwu-Jen Liou , Shorong-Shii Liou , Feng-Nien Ko
- Applicant: Chun-Nan Lin , Che-Ming Teng , Ing-Jun Chen , Shwu-Jen Liou , Shorong-Shii Liou , Feng-Nien Ko
- Applicant Address: TWX Taipei
- Assignee: National Science Council
- Current Assignee: National Science Council
- Current Assignee Address: TWX Taipei
- Main IPC: C07C45/46
- IPC: C07C45/46 ; C07C49/84 ; C07D311/86 ; C07H17/04 ; C07H15/244
Abstract:
A compound, and salts thereof, represented by either formula I or formula II below:(1) Formula I: ##STR1## wherein substituents R.sub.1 -R.sub.7 can be, independently, hydrogen, hydroxy group, C.sub.1-6 alkyl(oxy) group, acetyl ester, or C.sub.1-12 alkyl propanolamine; at least three but no more than four of the substituents are alkyl(oxy) group, hydroxyl group or acetyl ester; no more than one of the substituents can be C.sub.1-12 alkyl propanolamines; R.sub.1, R.sub.3, R.sub.7 cnnnot all be hydroxy groups at the same time; and R.sub.6 is either an hydroxy group or an oxygen-containing glucose.(2) Formula II: ##STR2## wherein substituents R.sub.1 -R.sub.9 can be, indenpendently, hydrogen, hydroxy group and C.sub.1-6 alkyl(oxy) group; and no more then four of the substituents can be methoxy group, hydroxy group, or acetyl ester. These compounds were tested to be capable of inhibiting platelet aggregation, atrioventricular conduction, and calcium influx in myocardiac cells.
Public/Granted literature
- US4753359A Tamper-proof cap and bottle Public/Granted day:1988-06-28
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