利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

28 条记录 (耗时 0.014 秒)

    Anti-fungal pharmaceutical compositions comprising an active ingredient prepared from Zingiber officinale
    1.
    发明授权
    Anti-fungal pharmaceutical compositions comprising an active ingredient prepared from Zingiber officinale 失效
    抗真菌药物组合物，其包含由姜科药剂制备的活性成分

    公开(公告)号：US06946153B2

    公开(公告)日：2005-09-20

    申请号：US10438233

    申请日：2003-05-14

    申请人： Tian-Shung Wu ,  Sheng-Chu Kuo ,  Che-Ming Teng ,  Feng-Nien Ko

    发明人： Tian-Shung Wu ,  Sheng-Chu Kuo ,  Che-Ming Teng ,  Feng-Nien Ko

    IPC分类号： A61K36/9066 ,  A61K35/78

    CPC分类号： A61K36/9068 ,  A61K36/9066 ,  Y10S514/864

    摘要： A method of treating a patient suffering a disease associated with Trichophyton mentagrophytes or Pityrosporum ovale by applying topically an anti-fungal pharmaceutical composition which is prepared from Zingiber officinale, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO2, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.

    摘要翻译： 通过局部施用由姜科药剂制备的抗真菌药物组合物治疗患有与毛癣菌相关的疾病的患者的方法包括以下步骤：通过用有机物提取从姜的根茎制备粗液体 溶剂或超临界CO 2，或通过蒸汽蒸馏; 将粗液体引入反相色谱柱，并用水洗脱柱，第一洗脱液和第二洗脱液，其极性弱于第一洗脱液的极性，但比氯仿强烈，使得从洗脱产生的第一洗脱液 的第一洗脱液和由第二洗脱液洗脱产生的第二洗脱液; 通过蒸发分别从第一洗脱液和第二洗脱液除去第一洗脱液和第二洗脱液，使得获得第一浓缩洗脱液和第二浓缩洗脱液作为有效提取物。

    Use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori
    5.
    发明申请
    Use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori 有权
    使用从姜黄根茎提取的有效产品治疗与幽门螺杆菌相关的疾病

    公开(公告)号：US20090104293A1

    公开(公告)日：2009-04-23

    申请号：US11907854

    申请日：2007-10-18

    申请人： Feng-Nien Ko ,  Mo-Chi Cheng ,  Cheng-Ko Liu ,  Jen-Wei Chen ,  Fen Chen ,  Chao-Chi Yei

    发明人： Feng-Nien Ko ,  Mo-Chi Cheng ,  Cheng-Ko Liu ,  Jen-Wei Chen ,  Fen Chen ,  Chao-Chi Yei

    IPC分类号： A61K36/9068 ,  A61P43/00

    CPC分类号： A61K36/9068

    摘要： The present invention discloses a new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a reverse phase chromatography column, and eluting the column with a first eluent having a polarity lower than water to obtain a first potent fraction or a second eluent having a polarity lower than that of the first eluent to obtain a second potent fraction. Preferably, the second potent fraction is substantially free of both 6-gingerol and 6-shogaol.

    摘要翻译： 本发明公开了一种从姜黄根提取的有效产品在治疗与幽门螺杆菌相关的疾病如胃炎，胃溃疡或十二指肠溃疡中的新用途。 所述有效产物通过以下步骤制备，所述方法包括以下步骤：a）从姜黄根茎制备粗提取物，所述粗提物包含6-姜醇和6-shogaol; b）将粗提取物引入反相层析柱，并用极性低于水的第一洗脱液洗脱柱，以获得极性低于第一洗脱液的第一有效级分或第二洗脱液，从而获得 第二有效分数。 优选地，第二有效级分基本上不含6-姜醇和6-shogaol。

    Anti-depression pharmaceutical composition containing Polygala extract
    6.
    发明授权
    Anti-depression pharmaceutical composition containing Polygala extract 有权
    抗抑郁药物组合物含有Polygala提取物

    公开(公告)号：US07179496B2

    公开(公告)日：2007-02-20

    申请号：US10915464

    申请日：2004-08-11

    申请人： Feng-Nien Ko ,  Cheng-Ko Liu ,  Yu-Feng Han ,  Pin-Fun Chen

    发明人： Feng-Nien Ko ,  Cheng-Ko Liu ,  Yu-Feng Han ,  Pin-Fun Chen

    IPC分类号： A61K35/78

    CPC分类号： A61K36/69 ,  A61K2300/00

    摘要： A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.

    摘要翻译： 药物组合物含有治疗有效量的活性成分，与活性成分的药学上可接受的载体或稀释剂混合，其中活性成分是i）Polygala的极性溶剂提取物，极性溶剂是水或混合物 的水和甲醇或乙醇; ii）由有机溶剂萃取极性溶剂提取物得到的水性级分; iii）通过将极性溶剂提取物或水性级分引入反相色谱柱中，并用水和有机溶剂洗脱柱来进行有机洗脱液; 或iv）在有机洗脱液中分子量小于30000的滤液。

    Anti-depression pharmaceutical composition containing polygala extract
    7.
    发明授权
    Anti-depression pharmaceutical composition containing polygala extract 有权
    抗抑郁药物组合物含有多甙提取物

    公开(公告)号：US06911222B2

    公开(公告)日：2005-06-28

    申请号：US10335920

    申请日：2003-01-03

    申请人： Feng-Nien Ko ,  Cheng-Ko Liu ,  Yu-Feng Han ,  Pin-Fun Chen

    发明人： Feng-Nien Ko ,  Cheng-Ko Liu ,  Yu-Feng Han ,  Pin-Fun Chen

    IPC分类号： A61K36/18 ,  A61K36/69 ,  A61P25/24 ,  C11B9/02 ,  A61K35/78

    CPC分类号： A61K36/69 ,  A61K2300/00

    摘要： A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.

    摘要翻译： 药物组合物含有治疗有效量的活性成分，与活性成分的药学上可接受的载体或稀释剂混合，其中活性成分是i）Polygala的极性溶剂提取物，极性溶剂是水或混合物 的水和甲醇或乙醇; ii）由有机溶剂萃取极性溶剂提取物得到的水性级分; iii）通过将极性溶剂提取物或水性级分引入反相色谱柱中，并用水和有机溶剂洗脱柱来进行有机洗脱液; 或iv）在有机洗脱液中分子量小于30000的滤液。

    Method of preparing an extract potent in anti-inflammation and anti-platelet aggregation from Zingiber officinale and pharmaceutical compositions containing said extract
    8.
    发明授权
    Method of preparing an extract potent in anti-inflammation and anti-platelet aggregation from Zingiber officinale and pharmaceutical compositions containing said extract 失效
    制备强效抗锌和抗血小板聚集的提取物的方法，所述提取物含有所述提取物

    公开(公告)号：US06274177B1

    公开(公告)日：2001-08-14

    申请号：US09648662

    申请日：2000-08-26

    申请人： Tian-Shung Wu ,  Sheng-Chu Kuo ,  Che-Ming Teng ,  Feng-Nien Ko

    发明人： Tian-Shung Wu ,  Sheng-Chu Kuo ,  Che-Ming Teng ,  Feng-Nien Ko

    IPC分类号： A61K3578

    CPC分类号： A61K36/9068

    摘要： A method of preparing an extract from Zingiber officinale, which is potent in anti-inflammation and anti-platelet aggregation, includes the following steps: a) preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or by distillation with steam; b) introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; c) removing the first eluent from the first eluate by evaporation, so that a first concentrated eluate is obtained and is able to used as the potent extract; and d) removing the second eluent from the second eluate by evaporation, so that a second concentrated eluate is obtained and is able to used as the potent extract.

    摘要翻译： 一种制备抗炎和抗血小板聚集有效的姜科提取物的方法，包括以下步骤：a）通过用有机溶剂萃取或用蒸汽蒸馏，从姜的根茎制备粗液; b）将粗液引入反相层析柱，并用水洗脱柱，第一洗脱液和第二洗脱液的极性比第一洗脱液的极性弱，但比氯仿强烈，使得第一洗脱液得到 从第一洗脱液的洗脱和第二洗脱液洗脱得到的第二洗脱液得到; c）通过蒸发从第一洗脱液中除去第一洗脱液，从而获得第一浓缩洗脱液并且能够用作有效提取物; 和d）通过蒸发从第二洗脱液中除去第二洗脱液，从而获得第二浓缩洗脱液并且能够用作有效提取物。

    Use of a potent product extracted from rhizomes of zingiber officinale in treating a disease associated with Helicobacter pylori
    9.
    发明授权
    Use of a potent product extracted from rhizomes of zingiber officinale in treating a disease associated with Helicobacter pylori 有权
    使用从姜黄根茎提取的有效产品治疗与幽门螺杆菌相关的疾病

    公开(公告)号：US08470379B2

    公开(公告)日：2013-06-25

    申请号：US12911143

    申请日：2010-10-25

    申请人： Feng-Nien Ko ,  Mo-Chi Cheng ,  Cheng-Ko Liu ,  Jen-Wei Chen ,  Fen Chen ,  Chao-Chi Yei

    发明人： Feng-Nien Ko ,  Mo-Chi Cheng ,  Cheng-Ko Liu ,  Jen-Wei Chen ,  Fen Chen ,  Chao-Chi Yei

    IPC分类号： A61K36/9068

    CPC分类号： A61K36/9068

    摘要： A new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.

    摘要翻译： 从姜黄根茎提取的有效产品的新用途，用于治疗与幽门螺杆菌相关的疾病，如胃炎，胃溃疡或十二指肠溃疡。 所述有效产物通过以下步骤制备，所述方法包括以下步骤：a）从姜黄根茎制备粗提取物，所述粗提物包含6-姜醇和6-shogaol; b）将粗提取物引入正相色谱柱，并用具有极性低于正己烷和乙酸乙酯的混合物的第一洗脱液以6:4的重量比洗脱柱，以获得有效分数 。 优选地，有效部分基本上不含6-姜醇和6-硫醇。