发明授权
- 专利标题: Glucagon antagonists
- 专利标题(中): 胰高血糖素拮抗剂
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申请号: US937132申请日: 1992-08-27
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公开(公告)号: US5510459A公开(公告)日: 1996-04-23
- 发明人: Robert A. Smith , James R. Piggott
- 申请人: Robert A. Smith , James R. Piggott
- 申请人地址: WA Seattle
- 专利权人: ZymoGenetics, Inc.
- 当前专利权人: ZymoGenetics, Inc.
- 当前专利权人地址: WA Seattle
- 主分类号: C07K14/575
- IPC分类号: C07K14/575 ; C07K14/605 ; C12N1/19 ; C12N15/09 ; C12N15/16 ; C12P21/02 ; C12R1/865 ; G01N33/53 ; A61K38/26 ; C07K14/00
摘要:
Methods for detecting glucagon antagonists through the use of recombinant DNA techniques are provided. Briefly, subsequent to the expression of glucagon analogs within suitable host cells, the analogs are exposed to a glucagon receptor coupled to a response pathway in the presence of native glucagon. A reduction in the stimulation of the response pathway resulting from the binding of the glucagon analog to the glucagon receptor relative to the stimulation of the response pathway by native glucagon alone indicates the presence of a glucagon antagonist. Glucagon antagonists identified and isolated through the methods are also provided.
公开/授权文献
- USD300232S Toy musical instrument 公开/授权日:1989-03-14