发明授权
- 专利标题: Tricyclic 2,3,4,5-tetrahydro-1H-3-benzapines
- 专利标题(中): 三环2,3,4,5-四氢-1H-3-苯偶氮
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申请号: US202401申请日: 1994-02-24
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公开(公告)号: US5512562A公开(公告)日: 1996-04-30
- 发明人: Rolf Hohlweg , Erik B. Nielsen
- 申请人: Rolf Hohlweg , Erik B. Nielsen
- 申请人地址: DKX Bagsvaerd
- 专利权人: Novo Nordisk A/S
- 当前专利权人: Novo Nordisk A/S
- 当前专利权人地址: DKX Bagsvaerd
- 优先权: DKX0267/93 19930310
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; A61P25/00 ; A61P25/18 ; A61P25/20 ; A61P25/24 ; A61P25/26 ; A61P43/00 ; C07D223/14 ; C07D223/32 ; C07D405/04 ; C07D491/04 ; C07D491/048 ; C07D491/056 ; C07D495/04 ; C07D498/04
摘要:
Tricyclic benzazepines having the general formula ##STR1## wherein A together with the .alpha.- and .beta.-marked carbon atoms is a cyclopentene, cyclohexene, furan, dihydrofuran, pyran, dihydropyran, thiophene, oxazole, pyrrole, pyrroline, tetrahydropyridine or dioxole ring, R.sup.1 is H or alkyl, R.sup.2 and R.sup.3 independently are H, alkoxy, halogen, nitro, cyano or hydroxy, or R.sup.2 and R.sup.3 together may form a furan, dihydrofuran, cyclopentene or dioxole ring and R.sup.4 is H, alkoxy, nitro, cyano, hydroxy or halogen, or a pharmaceutically acceptable salt thereof, are useful in treatment of certain disorders in the central nervous system, e.g., psychosis, pain, depression, sleep disturbances, dyskinesia, Parkinson's disease, stroke.
公开/授权文献
- US6008381A Process for preparing 3-isochromanone 公开/授权日:1999-12-28
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