发明授权
- 专利标题： Conotoxin peptides
- 专利标题（中）： 芋螺毒素肽
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申请号： US137800申请日： 1993-10-19
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公开(公告)号： US5514774A公开(公告)日： 1996-05-07
- 发明人: Baldomero M. Olivera , Lourdes J. Cruz , David R. Hillyard , J. Michael McIntosh , Ameurfina D. Santos
- 申请人： Baldomero M. Olivera , Lourdes J. Cruz , David R. Hillyard , J. Michael McIntosh , Ameurfina D. Santos
- 申请人地址： UT Salt Lake City
- 专利权人： University of Utah Research Foundation
- 当前专利权人： University of Utah Research Foundation
- 当前专利权人地址： UT Salt Lake City
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; A61K39/00 ; C07K7/06 ; C07K7/08 ; C07K14/435 ; C12N15/12 ; C07K7/00 ; A61K38/04
摘要：
The invention is directed to A-lineage conotoxin peptides, which are conotoxin peptides that have strong homology in the signal sequence and the 3'-untranslated region of the genes coding for these peptides to the sequences in the .alpha.-conotoxin peptides. The A-lineage conotoxin peptides include the .alpha.-conotoxin peptides, the .alpha.-conotoxin-like peptides and the .kappa.-conotoxin peptides, described further below. The .alpha.-conotoxin-peptides generally share a "core" sequence motif. This core sequence is termed the .alpha.3/5 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:1). The .alpha.-conotoxin-like peptides generally share a core sequence termed the .alpha.4/7 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:2). The .kappa.-conotoxin peptides generally have a core sequence termed the .kappa.7/2/1/3 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Cys-Xaa-Cys-Xaa-Xaa-Xaa-Cys (SEQ ID NO:3).
公开/授权文献
- US4360804A Pattern display system 公开/授权日：1982-11-23
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