发明授权
- 专利标题: Condensed pyrazole derivatives, and androgen inhibitor
- 专利标题(中): 缩合吡唑衍生物和雄激素抑制剂
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申请号: US373081申请日: 1995-01-17
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公开(公告)号: US5516777A公开(公告)日: 1996-05-14
- 发明人: Hiroshi Kiyokawa , Satoshi Yamada , Keisuke Miyajima , Koji Edamatsu , Kunihiko Tatsumi , Takeshi Yamauchi , Kazumasa Kishi , Kunihiko Kiyono
- 申请人: Hiroshi Kiyokawa , Satoshi Yamada , Keisuke Miyajima , Koji Edamatsu , Kunihiko Tatsumi , Takeshi Yamauchi , Kazumasa Kishi , Kunihiko Kiyono
- 申请人地址: JPX Tokyo
- 专利权人: Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人: Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX4-281446 19921020; JPX5-045424 19930305
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; A61K31/505
摘要:
This invention provides a condensed pyrazole derivative of the Formula (1): ##STR1## (where A denotes CH or N, R.sup.0 and R.sup.3 denote same or different, a hydrogen atom or a lower alkyl group, R.sup.1 and R.sup.2 denote same or different, a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group or a halogen atom, m denotes 1 or 2, and n denotes 1, 2 or 3, provided that, when n is 2, two R.sup.2 may be connected to each other to form a lower alkylenedioxy group), or its pharmaceutically acceptable salt. This derivative or its salt is excellent in the effect of inhibiting the expression of action of androgen, thereby being excellent in therapeutical effect of benign prostatic hypertrophy, prostatic carcinoma, etc., and has a long lasting of efficacy and high oral absorption.
公开/授权文献
- US4987862A Once-through steam generator 公开/授权日:1991-01-29
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