发明授权
- 专利标题： Process for preparing cyclic CIS-1-amino-2-alkanols
- 专利标题（中）： 制备环状CIS-1-氨基-2-链烷醇的方法
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申请号： US121340申请日： 1993-09-14
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公开(公告)号： US5516943A公开(公告)日： 1996-05-14
- 发明人: Yun Gao , Yaping Hong , Xiaoyi Nie , Roger P. Bakale , Richard R. Feinberg , Charles M. Zepp
- 申请人： Yun Gao , Yaping Hong , Xiaoyi Nie , Roger P. Bakale , Richard R. Feinberg , Charles M. Zepp
- 申请人地址： MA Marlborough
- 专利权人： Sepracor, Inc.
- 当前专利权人： Sepracor, Inc.
- 当前专利权人地址： MA Marlborough
- 主分类号： C07C213/08
- IPC分类号： C07C213/08 ; C07C233/23 ; C07C233/74 ; C07C209/58
摘要：
A two-step process for the conversion of a trans-1-amino-2-hydroxycycloalkane stereoselectively to a cis-1-amino-2-hydroxycycloalkane is disclosed. The novel step, a one-step hydrolysis with formal inversion, can be used to convert an amide of a trans-1-amino-2-hydroxycycloalkane to a cis-1-amino-2-hydroxycycloalkane. Methods for obtaining the trans-1-amino-2-hydroxycycloalkanes and their amides from alkenes are also disclosed. A preferred process converts indene to cis-1-amino-2-indanol.
公开/授权文献
- US5984250A Latch hook 公开/授权日：1999-11-16
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