发明授权
US5521291A Conjugates for introducing nucleic acid into higher eucaryotic cells
失效
用于将核酸引入高级真核细胞的缀合物
- 专利标题： Conjugates for introducing nucleic acid into higher eucaryotic cells
- 专利标题（中）： 用于将核酸引入高级真核细胞的缀合物
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申请号： US166899申请日： 1993-12-15
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公开(公告)号： US5521291A公开(公告)日： 1996-05-28
- 发明人: David T. Curiel , Ping-chuan Hu , Max L. Birnstiel , Matthew Cotten , Ernst Wagner
- 申请人： David T. Curiel , Ping-chuan Hu , Max L. Birnstiel , Matthew Cotten , Ernst Wagner
- 申请人地址： DEX South San Francisco CA South San Francisco NC Chapel Hill
- 专利权人： Boehringer Ingelheim International, GmbH,Genentech, Inc.,University of North Carolina at Chapel Hill
- 当前专利权人： Boehringer Ingelheim International, GmbH,Genentech, Inc.,University of North Carolina at Chapel Hill
- 当前专利权人地址： DEX South San Francisco CA South San Francisco NC Chapel Hill
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; C07K16/08 ; C12N15/87 ; A61K39/42 ; C07H19/00 ; C12N7/00
摘要：
Conjugates in which a virus is bound via an antibody to a substance having an affinity for nucleic acid, for transporting gene constructs into higher eucaryotic cells. Complexes of the conjugates and nucleic acid are internalized in the cell, whilst the virus as part of the complex brings about the internalization and the release of the contents of the endosomes, in which the complexes are located after entering the cell. Pharmaceutical preparations in which the nucleic acid is a therapeutically active gene construct, particularly for use in gene therapy.
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