发明授权
- 专利标题： Process for P-nitrobenzyl ester cleavage in cephalosporin
- 专利标题（中）： 头孢菌素中对硝基苄酯切割的方法
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申请号： US453911申请日： 1995-05-30
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公开(公告)号： US5536830A公开(公告)日： 1996-07-16
- 发明人: Jag M. Khanna , Yatendra Kumar , Rakesh K. Arora , Neera Tiwari , Shailendra K. Singh
- 申请人： Jag M. Khanna , Yatendra Kumar , Rakesh K. Arora , Neera Tiwari , Shailendra K. Singh
- 申请人地址： INX New Delhi
- 专利权人： Ranbaxy Laboratories, Ltd.
- 当前专利权人： Ranbaxy Laboratories, Ltd.
- 当前专利权人地址： INX New Delhi
- 优先权： INX474/94 19940422
- 主分类号： C07D501/00
- IPC分类号： C07D501/00 ; C07D501/04
摘要：
A process for converting cephalosporin p-nitrobenzyl ester (Formula I) to the corresponding cephalosporin free acid (Formula II) comprising treating the cephalosporin p-nitrobenzyl ester with a metal selected from the group consisting of iron, magnesium, aluminum, and tin, and with hydrochloric acid in a mixture of water and a water-miscible organic solvent. Preferably, the metal is iron in the form of a fine powder, and the reaction is carried out at a temperature in the range of 30.degree.-50.degree. C.
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