中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

7 records (took 0.011 seconds)

    Process for P-nitrobenzyl ester cleavage in cephalosporin
    5.
    发明授权
    Process for P-nitrobenzyl ester cleavage in cephalosporin 失效
    头孢菌素中对硝基苄酯切割的方法

    公开(公告)号：US5536830A

    公开(公告)日：1996-07-16

    申请号：US453911

    申请日：1995-05-30

    Applicant: Jag M. Khanna ,  Yatendra Kumar ,  Rakesh K. Arora ,  Neera Tiwari ,  Shailendra K. Singh

    Inventor： Jag M. Khanna ,  Yatendra Kumar ,  Rakesh K. Arora ,  Neera Tiwari ,  Shailendra K. Singh

    IPC: C07D501/00 ,  C07D501/04

    CPC classification number: C07D501/00

    Abstract: A process for converting cephalosporin p-nitrobenzyl ester (Formula I) to the corresponding cephalosporin free acid (Formula II) comprising treating the cephalosporin p-nitrobenzyl ester with a metal selected from the group consisting of iron, magnesium, aluminum, and tin, and with hydrochloric acid in a mixture of water and a water-miscible organic solvent. Preferably, the metal is iron in the form of a fine powder, and the reaction is carried out at a temperature in the range of 30.degree.-50.degree. C.

    Abstract translation: 一种将头孢菌素对硝基苄基酯（式I）转化成相应的头孢菌素游离酸（式II）的方法，包括用选自铁，镁，铝和锡的金属处理头孢菌素对硝基苄酯，以及 用盐酸与水和水混溶的有机溶剂的混合物。 优选地，金属是细粉末形式的铁，并且反应在30-50℃的温度下进行。

    Process for preparing Z and E-rotamers of 3-hydroxy cephem derivatives
    6.
    发明授权
    Process for preparing Z and E-rotamers of 3-hydroxy cephem derivatives 失效
    制备3-羟基头孢烯衍生物的Z和E旋转异构体的方法

    公开(公告)号：US5410044A

    公开(公告)日：1995-04-25

    申请号：US19269

    申请日：1993-02-18

    Applicant: Jag M. Khanna ,  Yatendra Kumar ,  Arun Malhotra ,  Rakesh Arora ,  Neera Tiwari

    Inventor： Jag M. Khanna ,  Yatendra Kumar ,  Arun Malhotra ,  Rakesh Arora ,  Neera Tiwari

    IPC: C07D501/00 ,  C07D501/04 ,  C07D501/59

    CPC classification number: C07D501/00

    Abstract: A process for the manufacture of 7-acylamino-3-hydroxycephem-4-carboxylate-1-oxide in E-rotamer form (Formula III), comprises reacting a 7-acylamino-3-exomethylenecepham-4-carboxylate-1-oxide with ozone in an inert organic solvent in the presence of a catalytic amount of an organic or inorganic base at a temperature ranging from about -80.degree. C. to about +20.degree. C. The E-rotamer (wherein the 3-hydroxy group is strongly hydrogen bonded to the carbonyl of the 4-ester group) exhibits different chemical and physical properties from and is more thermodynamically stable than, the Z-rotamer (wherein there is no hydrogen bonding between the 3-hydroxy group and the carbonyl of the 4-ester group).

    Abstract translation: 以旋转异构体形式（式III）制备7-酰基氨基-3-羟基头孢-4-羧酸-1-氧化物的方法包括使7-酰基氨基-3-异亚甲基头孢-4-羧酸-1-氧化物与 臭氧在惰性有机溶剂中，在约-80℃至约+20℃的温度范围内，在催化量的有机或无机碱的存在下进行.E-旋转异构体（其中3-羟基是强的 与4-酯基的羰基键合的氢）与Z-旋转异构体（其中3-羟基与4-羟基的羰基之间不存在氢键）具有不同的化学和物理性能，并且比热稳定性更强， 酯基）。

    E-rotamers of 3-hydroy cephem derivatives
    7.
    发明授权
    E-rotamers of 3-hydroy cephem derivatives 失效
    3-羟基头孢烯衍生物的电子旋转异构体

    公开(公告)号：US5631367A

    公开(公告)日：1997-05-20

    申请号：US402095

    申请日：1995-03-10

    Applicant: Jag M. Khanna ,  Yatendra Kumar ,  Arun Malhotra ,  Rakesh Arora ,  Neera Tiwari

    Inventor： Jag M. Khanna ,  Yatendra Kumar ,  Arun Malhotra ,  Rakesh Arora ,  Neera Tiwari

    IPC: C07D501/00 ,  C07D501/04 ,  C07D501/59

    CPC classification number: C07D501/00

    Abstract: A process for the manufacture of 7-acylamino-3-hydroxy-cephem-4-carboxylate-1-oxide in E-rotamer form (Formula III), comprises reacting a 7-acylamino-3-exomethylenecepham-4-carboxylate-1-oxide with ozone in an inert organic solvent in the presence of a catalytic amount of an organic or inorganic base at a temperature ranging from about -80.degree. C. to about +20.degree. C. The E-rotamer (wherein the 3-hydroxy group is strongly hydrogen bonded to the carbonyl of the 4-ester group) exhibits different chemical and physical properties from and is more thermodynamically stable than, the Z-rotamer (wherein there is no hydrogen bonding between the 3-hydroxy group and the carbonyl of the 4-ester group).

    Abstract translation: 用于制备E-旋转异构体形式的7-酰基氨基-3-羟基 - 头孢烯-4-羧酸酯-1-氧化物的方法（式III）包括使7-酰基氨基-3-异亚甲基头孢-4-羧酸酯-1-氧化物 氧化物与臭氧在惰性有机溶剂中，在约-80℃至约+20℃的温度范围内，在催化量的有机或无机碱存在下进行。该E-旋转异构体（其中3-羟基 与4-酯基团的羰基结合的强氢键）表现出与Z-旋转异构体（其中3-羟基和羰基之间没有氢键）的化学和物理性质不同，并且比热稳定性更强 4-酯基）。

Patent Agency Ranking